Results 271 to 280 of about 31,917,810 (358)

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

High-Efficiency Traceability Mechanism for Multimedia Data in Consumer Internet of Things Combined with Blockchain. [PDF]

Sensors (Basel)
Yan T, Chen J, Zhang X, Hu G.
europepmc   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

Carbon foam derived from co-carbonization of lignin and petroleum asphalt for high-efficiency solar evaporators. [PDF]

RSC Adv
Shang J, Qu W, Liang C, Yin L, Li M, Liu J.   +5 more
europepmc   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

FEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee, Ga Seul Lee, JinHan Kim, Kwang‐Hyun Park, Seong‐Ryung Go, Jeong Hee Moon, Eui‐Jeon Woo   +6 more
wiley   +1 more source

High-efficiency methane consumption by atmospheric methanotrophs in subsurface karst caves: The irrefutable methane sink. [PDF]

Sci Adv
Liu X, Cheng X, Zhang Y, Zhao R, Wang W, Li Y, Chen ZQ, Qiu X, Tuovinen OH, Bull ID, Evershed RP, Wang H.   +11 more
europepmc   +1 more source

Development of High-Efficiency Perovskite Solar Cells and Their Integration with Machine Learning. [PDF]

Nanomaterials (Basel)
Gao S, Peng R, Ren K, Yu L, Jiang Q, Shen Z, Yue S, Wang Z.   +7 more
europepmc   +1 more source

High-efficiency and broadband Kerr comb generation in normal-dispersion x-cut lithium niobate microresonators. [PDF]

Sci Adv
Song Y, Li Z, Zhu X, Lippok N, Erkintalo M, Lončar M.   +5 more
europepmc   +1 more source