Results 61 to 70 of about 976,997 (264)
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
High-Power-Density, High-Energy-Density Fluorinated Graphene for Primary Lithium Batteries [PDF]
Frontiers in Chemistry, 2018 Li/CFx is one of the highest-energy-density primary batteries; however, poor rate capability hinders its practical applications in high-power devices. Here we report a preparation of fluorinated graphene (GFx) with superior performance through a direct gas fluorination method.
Guiming Zhong +8 more
openaire +3 more sources
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Critical Point Fluctuations in Heavy-Ion Collisions within Molecular Dynamics with Expansion [PDF]
EPJ Web of ConferencesWe analyze particle number fluctuations near the critical endpoint of a first-order phase transition using molecular dynamics simulations of the Lennard-Jones fluid. Building on our previous study [V.A. Kuznietsov et al., Phys. Rev. C 105, 044903 (2022)],
Kuznietsov Volodymyr A. +3 more
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Nuclear FusionUnderstanding interaction between transmutation elements and helium is critically important for precisely predicting the performance of tungsten plasma facing materials in fusion reactors.
Yanyao Zhou, Gui-Yang Huang, Xunxiang Hu
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
All-optical structuring of laser-driven proton beam profiles
Nature Communications, 2018 Shaping particle beams generated from laser-plasma accelerators is challenging. Here the authors demonstrate an all-optical method to structure the accelerated proton beam by modulating and imprinting the spatial laser profile onto the proton beam.
Lieselotte Obst-Huebl +25 more
doaj +1 more source
Physics and Phenomenology of Weakly Magnetized, Relativistic Astrophysical Shock Waves
Galaxies, 2020 Weakly magnetized, relativistic collisionless shock waves are not only the natural offsprings of relativistic jets in high-energy astrophysical sources, they are also associated with some of the most outstanding displays of energy dissipation through ...
Arno Vanthieghem +6 more
doaj +1 more source