Results 51 to 60 of about 2,043,112 (192)

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

High-energy hadron physics at future facilities

open access: yes, 2007
We outline several directions for future investigations of the three-dimensional structure of nucleon, including multiparton correlations, color transparency, and branching processes at hadron colliders and at hadron factories. We also find evidence that
Abe   +20 more
core   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

open access: yesMolecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni   +11 more
wiley   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

open access: yesMolecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu   +10 more
wiley   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

open access: yesFEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini   +2 more
wiley   +1 more source

HEPS scientific computing platform design for interactive data analysis scenarios [PDF]

open access: yesEPJ Web of Conferences
The High Energy Photon Source (HEPS), located at Beijing HuaiRou, is an advanced public platform for multidisciplinary innovation research and high-tech development, as well as understanding many scientific questions in the fields of physics, chemistry ...
Hu Qingbao   +5 more
doaj   +1 more source

High Voltage in Noble Liquids for High Energy Physics

open access: yes, 2014
A workshop was held at Fermilab November 8-9, 2013 to discuss the challenges of using high voltage in noble liquids. The participants spanned the fields of neutrino, dark matter, and electric dipole moment physics.
A Tomas   +15 more
core   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

open access: yesFEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj   +3 more
wiley   +1 more source

Using Kerberos Tokens in Distributed Computing System at IHEP [PDF]

open access: yesEPJ Web of Conferences
The token-based certification method is spreading in the distributed computing system of high energy physics. More and more software and middleware are supporting tokens as one of the certification methods.
Jiang Xiaowei   +5 more
doaj   +1 more source

Measurement of the cross section of e + e − → ηπ + π − at center-of-mass energies from 3.872 GeV to 4.700 GeV

open access: yesJournal of High Energy Physics, 2022
Using data samples with an integrated luminosity of 19 fb −1 at twenty-eight center-of-mass energies from 3.872 GeV to 4.700 GeV collected with the BESIII detector at the BEPCII electron-positron collider, the process e + e − → ηπ + π − and the ...
The BESIII collaboration   +574 more
doaj   +1 more source

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