Results 31 to 40 of about 21,600,427 (264)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...Lukas Drexler, Markus R. Busch, Reinhard Sterner +2 morewiley +1 more sourcePeripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini +8 morewiley +1 more sourceHigh Energy Physics Division semiannual report of research activities, July 1, 1991--December 31, 1991 [PDF]
, 1992 This report describes the research conducted in the High Energy Physics Division of Argonne National Laboratory during the period of July 1, 1991--December 31, 1991.Wagner, R., Schoessow, P., Moonier, P., Talaga, R. +3 morecore +1 more sourcePartial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig +10 morewiley +1 more sourceThe MICE Muon Beam on ISIS and the beam-line instrumentation of the Muon Ionization Cooling Experiment [PDF]
, 2012 The international Muon Ionization Cooling Experiment (MICE), which is under construction at the Rutherford Appleton Laboratory (RAL), will demonstrate the principle of ionization cooling as a technique for the reduction of the phase-space volume occupied A. Wilson, Colling D, Tsenov R, M. Hills, R. Apsimon, Gamet, R., Kyberd, P., T. L. Hart, Grichine, V., S. Ramberger, R. Nicholson, W. Spensley, D. Cline, Wisting, H, Fletcher R, Hanke, K, V. Palladino, M. Khaleeq, Onel, Y, P. Smith, Kaplan DM, Colling, D., M. Littlefield, Kolev, D, Yang, X., Baynham, DE, Kim, Y. K., White C, Kasey V, E. McKigney, T. Savidge, Seviour, R, Sato A, Rimmer, R A, C. Heidt, White, C, Back, J, D. A. Sanders, Beuselinck, R, J. Alexander, Nichols, A., de Bari A, R. Fletcher, Ferri, F., Garoby, R., Onel, Y., Lee, K, Owens, P., D. Forrest, Neuffer D, Iaciofano, A, Mori, Y., Yoshimura, K, Onel Y, Cremaldi, L M, A. Jamdagni, R. Edgecock, Walaron, K., Verguilov V, Boyd S, Y. Karadzhov, Nelson C, Zisman, M S, Adey, D., Kirk, H, Zisman, M. S., Palladino, V., Rimmer, R.A., Tonazzo A, Cline, D., Masciocchi F, Mori Y, M. Vretenar, Savidge, T, Kolev, D., Tunnell, C D, Bogomilov, M, Forrest D, Apollonio, M., Cummings, MAC, Lombardi, A., Carlisle, T., Palladino, V, Lau, W, Tilley, K., Virostek, S., D. Adams, Yang, S., Dornan, P., Pastore F, Ramberger S, R. B. Palmer, Zheng SX, Wilson, A, Cooke, P, Kolev D, Lucchini G, Sandstrom, R, Gamet, R, Cobb, JH, Zheng, S.X., Edgecock R, Hanson, G.G., Charnley, G., A. Moss, Cooke P, DeMello A, Hart, TL, Witte H, Harrison, P, Verguilov, V, McKigney, E., Bonesini, M, Manfredini, A, Gregoire, G, Howlett L, Cirillo A, Rochford, J H, de Bari, A, ORESTANO, DOMIZIA, Long, K, Torun Y, Snopok, P., Cline, D, R. Beuselinck, Forrest, D, J. Leaver, Cummings, M A C, Nichols, A, Xu, F Y, Cummings, M. A. C., Xu, FY, Popovic, M., Back J, Hayler, T, Cooke, P., Y. Fukui, Collaboration, MICE, Kafka, G., M. Courthold, Nelson, C., K. Yoshimura, Bene P, Gilardoni S, Barber, G, R. Mazza, Parisi M., Summers DJ, Bogomilov, M., C. Nelson, Ramberger, S., Vretenar M, Adams, D., Savidge, T., Seviour, Rebecca, Hanson, GG, Hodgson P, A. Tonazzo, Cecchet, G., Ellis, M, Cremaldi, L.M., S. Blot, Janot, P, Fukui Y, M. Rayner, D. Huang, Strati, F., Courthold, M, Freemire, B., S. York, A. Lintern, F. Cadoux, Petitjean, C, Filthaut, F, Jamdagni A, R. Gamet, H. Haseroth, Yano T, Ishimoto, S., Y. Mori, Y. Ivaniouchenkov, Rimmer RA, Xu FY, Boyd, S, Graulich JS, Gamet R, Harrison P, Virostek, S, A. Dobbs, Cummings MAC, Hills, M, Carlisle, T, G. Kafka, Parisi, M, Nebrensky, J.J., Nebrensky JJ, Kuno, Y, Graulich, J.S., Graulich J-, Pasternak J, Kaplan, D. M., Lau W, Dobbs A, P. Dornan, P. Harrison, Hart, T. L., Oates, A., Cremaldi, L. M., Lombardi A, Xu, F.Y., Kim, YK, T. Hayler, F. J. P. Soler, L. Howlett, Haseroth, H., J. Gallardo, Yano, T, Martlew B, Barclay, P, Kaplan, D M, R. Garoby, P. Bene, G. Cecchet, C. D. Tunnell, U. Bravar, Nebrensky, J J, Orestano, D, Apollonio M, M. A. C. Cummings, Courthold, M., B. Freemire, Haseroth H, P. Barclay, Filthaut, F., Tortora, L, Greenwood, S., Soler, F.J.P., F. Y. Xu, Hayler, T., Palmer, RB, M. Parisi, V. Verguilov, Rayner, M., Tunnel, C.D., V. Kasey, Jones A, Kyberd, P, Wang, L, Fayer, S, Mazza, R, Littlefield, M., Hanson, G G, Mazza R, Blackmore V, K. Walaron, Vankova-Kirilova, G., Ivaniouchenkov, Y, Ivaniouchenkov Y, Griffiths, S., Ramberger, S, York, S., Gilardoni, S, Russinov, I, Heidt C, Nicholson, R., Bari Ad, Rochford, J. H., Tunnell CD, Filthaut F, Strati, F, Suzuki, S., Geer, S, S. Griffiths, Li D, Witte, H, Drumm, P, V. Grichine, Bogomilov M, T. Carlisle, D. Li, Li, D, Hodgson, P., E. Gschwendtner, Pastore, F, Zisman, M.S., Howlett, L, Kafka, G, Rayner, M, A. Alekou, Kim, Y K, Graulich, J -S, Wilson, A., Iaciofano A, Forrest, D., Fish, A., Moss A, Rimmer, RA, L. M. Cremaldi, V. Blackmore, Grichine V, Coney, L., D. Kolev, Summers, DJ, C. MacWaters, Jones, A., Clark I, P. Cooke, Witte, H., Clark D, Iaciofano, A., Courthold M, Lombardi, A, Lucchini, G., Alexander, J, Hare, R., Capponi, M, Yoshimura K, Capponi, M., Matsushita, T., D. Neuffer, Parisi M, Soler FJP, Lintern, A., Fletcher, R., Cecchet, G, G. Lucchini, Cadoux F, Vretenar, M, Y. Torun, Cremaldi, LM, Vretenar, M., A. Sato, Bross, A. D. (Alan D.), Paleari, F., Zisman, MS, Smith, P, Roberts, T. J., Petitjean, C., MacWaters, C., Moss, A, Ferri F, M. Takahashi, Seviour R, K. Tilley, Palmer, R.B., Kasey, V., Neuffer, D., Kafka G, Littlefield, M, R. Sandstrom, A. D. Bross, Rochford, J.H., Fish, A, Wilson A, Clark, D, Vankova-Kirilova, G, F. Paleari, Kyberd P, Cirillo, A., Rimmer, R. A., Roberts, TJ, Haseroth, H, D. J. Summers, Pasternak, J., S. Virostek, Clark, I, G. Vankova Kirilova, C. Rogers, W. Lau, de Bari, A., Strati F, Bertoni, R., M. Ellis, Rochford JH, Geer, S., Suzuki, S, Blondel, A, Kim, Y.K., Kahn S, Preece R, Yang X, A. Oates, Karadzhov, Y., Jones, A, P. Kyberd, Capponi M, Sashalmi, T, Yang S, Sashalmi, T., A. Iaciofano, Gilardoni, S., Moretti, A., P. Owens, Hills M, Paleari F, Matsushita T, Snopok, P, B. Martlew, Cadoux, F, Grichine, V, Robinson M, Green MA, L. Coney, Masciocchi, F., Blot, S., Cremaldi LM, Lee, K., Cecchet G, McKigney E, Bravar, U, G. Charnley, S. Fayer, Kahn, S, Sato, A., Tunnell, C. D., Bari, A de, Ivaniouchenkov, Y., Preece, R., Jamdagni, A, I. Russinov, Baynham, D. E., Torun, Y., R. A. Rimmer, Manfredini A, Owens, P, J. Pasternak, A. DeMello, A. Jones, Virostek S, Sandstrom R, S. Ricciardi, Bene, P, Leaver, J, Spensley, W., Bravar, U., Karadzhov, Y, Nebrensky, J. J., P. Gruber, Fletcher, R, Y. K. Kim, Gallardo J, Matsushita, T, Martlew, B, Seviour, R., Wang, L., Zisman MS, Soler, F. J. P., Nichols A, Palmer, R. B., G. Gregoire, Harrison, P., Tonazzo, A., Rogers, C, Manfredini, A., M. Bogomilov, Heidt, C, Bradshaw, TW, Booth, C N, D. Colling, T. Matsushita, Kahn, S., Hare, R, Tortora L, J. Back, Nelson, C, A. Fish, Fukui, Y, Li, D., Graulich, J-S, P. Snopok, K. Long, Green, M. A., Mullacrane I, Janot, P., Wisting, H., White, C., R. Preece, Bravar U, Apsimon, R, Masciocchi, F, Hanlet, P, Ellis M, Kuno, Y., Kasey, V, H. Sakamoto, DE BARI, ANTONIO, Lintern A, Cummings, M.A.C., Khaleeq, M, Robinson, M, Booth, C.N., Gallardo, J, Roberts TJ, Griffiths S, Preece, R, Vankova Kirilova G, Apsimon R, Apsimon, R., Summers, D. J., S. Kahn, Overton, E., Gruber, P., Lau, W., Gruber, P, Sanders, D A, PARISI, Mario, M. Bonesini, Edgecock, R., F. Filthaut, Tarrant, J., Kuno Y, Dobbs, A, F. Ferri, Palmer RB, Bertoni, R, Huang, D, Ricciardi, S, Parisi, M., York, S, Summers, D.J., F. Masciocchi, Howlett, L., J. S. Graulich, P. Hanlet, Yang, S, M. Popovic, Ishimoto, S, Bertoni R, Cirillo, A, Gregoire G, Apollonio, M, Boyd, S., Janot P, Orestano D, Leaver, J., E. Overton, Clark, D., Hanson, G. G., Yang, X, Back, J., Sanders, DA, T. W. Bradshaw, Martlew, B., J. J. Nebrensky, Coney, L, Gruber P, Bonesini, M., Y. Onel, Sanders, D.A., I. Clark, C. N. Booth, Cobb, J. H., Beuselinck R, G. Barber, Hills, M., S. Suzuki, Yoshida M, Sashalmi T, F. Pastore, Walaron, K, Soler, F J P, Paleari, F, A. Moretti, Russinov I, Geer S, Drumm P, Green, M A, Bradshaw TW, Sato, A, Karadzhov Y, Watson S, Alekou A, Yoshimura, K., Blondel, A., Mullacrane, I, A. Manfredini, M. Yoshida, Collomb N, M. Capponi, Sakamoto H, Dornan P, Kaplan, DM, Heidt, C., MICE Collaboration, Bradshaw, T.W., H. Witte, Overton, E, Harrison, P. F., Bross AD, Moretti A, Alexander J, Beuselinck, R., McKigney, E, Kaplan, D.M., DeMello, A, Takahashi M, Palladino V, Fish A, Hanson GG, Lintern, A, Summers, D J, Bross, A.D., Griffiths, S, Smith P, Ishimoto S, Drumm, P., Green, MA, Adams, D, H. Wisting, S. Boyd, T. Sashalmi, Adey D, Adey, David, Ph.D., I. Mullacrane, M. A. Green, Fukui, Y., Bonesini M, Alekou, A, Sakamoto, H., Charnley, G, Tonazzo, A, Moss, A., H. Kirk, Snopok P, MacWaters C, Mullacrane, I., D. M. Kaplan, Sandstrom, R., Huang, D., M. Robinson, Oates A, Collomb, N, Charnley G, M. Apollonio, Robinson, M., Popovic M, R. Bertoni, Owens P, Cadoux, F., Soler, FJP, Hanlet P, York S, Tunnell, CD, Tunnell, C.D., Colling, D, Hare R, D. Clark, Nicholson, R, Sanders DA, Ricciardi, S., Nicholson R, K. Hanke, P. Hodgson, Mori, Y, Long, K., Takahashi, M, T. J. Roberts, Petitjean C, DeMello, A., D. E. Baynham, Baynham DE, Gallardo, J., Zheng, SX, X. Yang, Hanke K, Hanke, K., Blot S, J. H. Rochford, Tilley K, Carlisle T, Clark, I., Bene, P., Overton E, Khaleeq M, Baynham, D.E., Pastore, F., Blondel A, Bari, A. de, Hayler T, Rogers, C., Booth, CN, R. Hare, S. Yang, Blackmore, V, Dobbs, A., Nebrensky, JJ, Suzuki S, Bross, A D, Ellis, M., Bradshaw, T W, Mazza, R., Blot, S, M. S. Zisman, Fayer S, Baynham, D E, Watson, S., Dornan, P, Gschwendtner, E., Greenwood, S, Khaleeq, M., L. Wang, Booth CN, P. Drumm, Tsenov, R, R. Tsenov, Yoshida, M, J. H. Cobb, Greenwood S, Palmer, R B, J. Tarrant, Barber, G., Collomb, N., Jamdagni, A., C. White, T. Yano, Vankova-Kirilova G, Moretti, A, MacWaters, C, K. Lee, Yoshida, M., R. Seviour, Russinov, I., S. X. Zheng, Rayner M, Cobb JH, Oates, A, D. Orestano, Orestano, D., Verguilov, V., Sakamoto, H, Tarrant, J, Edgecock, R, Lee K, Ferri, F, Neuffer, D, L. Tortora, Spensley, W, Adey, D, Yano, T., Alekou, A., Hart TL, Wisting H, Popovic, M, Roberts, T J, Y. Kuno, Kirk H, Adams D, C. Petitjean, Tilley, K, Back, J. J., Gschwendtner, E, F. Strati, Booth, C. N., G. G. Hanson, S. Watson, Cobb, J.H., Rochford, JH, Garoby R, Blackmore, V., A. Cirillo, A. Blondel, Huang D, Hodgson, P, Barber G, Green, M.A., Barclay P, Walaron K, Garoby, R, Savidge T, Freemire B, Smith, P., Wang L, Hanlet, P., Cline D, Pasternak, J, Barclay, P., Lucchini, G, N. Collomb, Zheng, S X, Watson, S, D. Adey, Hart, T.L., Coney L, A. Nichols, Ricciardi S, Freemire, B, A. Lombardi, Roberts, T.J., Boyd, Steve B., Torun, Y, Tarrant J, Gschwendtner E, P. Janot, Leaver J, Long K, Spensley W, Bross, AD, Fayer, S., Hart, T L, Takahashi, M., Kim YK, Cobb, J H, S. Ishimoto, Littlefield M, Tortora, L., Sanders, D. A., Rogers C, Tsenov, R., S. Gilardoni, Alexander, J., Gregoire, G., Kirk, H., S. Geer, S. Greenwood, PALLADINO, VITTORIO, Kolev D. +815 morecore +2 more sourcesEarly results of the LHCf Experiment and their contribution to Ultra-High-Energy Cosmic Ray Physics [PDF]
, 2010 LHCf is an experiment dedicated to the measurement of neutral particles emitted in the very forward region of LHC collisions. The physics goal is to provide data for calibrating hadron interaction models that are used in the study of Extremely High ...Tricomi, A., Adriani, Oscar, K. Noda, Macina, D., Suzuki, K., Faus Golfe, Ángeles, D'Alessandro, R., Velasco González, Jorge, Yasushi Muraki, Turner, W.C., Perrot, A.L., A.-L. Perrot, Mase, T., Castellini, G., Ricciarini, S., D. Macina, T. Suzuki, Haguenauer, M., A. Tricomi, Sako, T., Tamura, T., W.C. Turner, P. Papini, Kasahara, K., Noda, K., K. Masuda, T. Sako, O. Adriani, R. DʼAlessandro, K. Yoshida, Papini, P., A. Faus, K. Taki, Matsubara, Y., Suzuki, T., Velasco, J., S. Torii, Menjo, H., Muraki, Yasushi, Masuda, K., G. Castellini, G. Mitsuka, L. Bonechi, Shimizu, Y., Itow, Y., K. Suzuki, Y. Itow, Y. Shimizu, K. Kasahara, Nakai, M., Torii, S., Yoshida, K., Tricomi, Alessia, J. Velasco, Faus, A., Mitsuka, G., Bongi, M., M. Nakai, S. Ricciarini, M. Bongi, Adriani, O., Fukatsu, K., Taki, K., K. Fukatsu, M. Haguenauer, T. Tamura, Y. Matsubara, H. Menjo, T. Mase, Bonechi, L. +69 morecore +1 more source
