Results 121 to 130 of about 1,874,316 (354)
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Tumor mutational burden as a determinant of metastatic dissemination patterns
Molecular Oncology, EarlyView.This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal +4 more
wiley +1 more source
4.5 kW High Frequency Transformer Design for Dual Active Bridge (DAB)
Jurnal ElkomikaABSTRAK Indonesia bertujuan untuk beralih dari bahan bakar fosil ke sumber energi terbarukan, dengan target integrasi sebesar 23% pada tahun 2025 dan 31% pada tahun 2050.
NAUFAL HILMI FAUZAN +2 more
doaj +1 more source
Development of high frequency low weight power magnetics for aerospace power systems [PDF]
A dominant design consideration in the development of space type power mangetic devices is the application of reliable thermal control methods to prevent device failure which is due to excessive temperature rises and hot temperatures in critical areas ...
Schwarze, G. E.
core +1 more source
Signal path series step biased multidevice high efficiency amplifier Patent [PDF]
, 1971 High efficiency transformerless amplitude modulator coupled to RF power ...
Kubicz, A. P.
core +1 more source
Targeting p38α in cancer: challenges, opportunities, and emerging strategies
Molecular Oncology, EarlyView.p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley +1 more source
Design of a high‐frequency transformer based on amorphous cut cores for insulation breakdown testing
High VoltageInnovative test methods are required to keep up with the increased demand for insulation materials which can withstand the high‐frequency square‐wave voltages generated by power‐electronic equipment.
Gijs Lagerweij +1 more
doaj +1 more source
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
Design of a High Frequency Isolation Auxiliary Transformer for Urban Rail Vehicle
机车电传动, 2017 This paper introduced the design ideas of a high frequency isolation auxiliary transformer, and demonstrated its key design for core, windings, parasitic inductance, loss and so on.
ZHOU Shuai +4 more
doaj
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source