Results 111 to 120 of about 142,055 (307)
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Differential sound level meter [PDF]
, 1977 Small differences between relatively high sound pressure levels at two different microphone sites are measured by a device which provides electrical insertion voltages (pilot voltages) as a a means for continuously monitoring the gains of two acoustical ...
Zuckerwar, A. J.
core +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Chaos controller for switching regulators aiming enhanced design-space towards miniaturization [PDF]
, 2014 This paper tackles the control of fast-scale instabilities in a buck switching power converter aiming to expand its design-space towards miniaturization.
Alarcón Cot, Eduardo José +4 more
core +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Controllable high voltage source having fast settling time [PDF]
, 1975 A high voltage dc stepping power supply for sampling a utilization device such as an electrostatic analyzer has a relatively fast settling time for voltage steps. The supply includes a waveform generator for deriving a low voltage staircase waveform that
Acuna, M. H., Doong, H.
core +1 more source
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
Optimized power converters for electrically augmented on-orbit propulsion systems
, 2002 Advances in satellite thruster technology have produced the requirement for high power electrical supplies to operate electrically augmented on-orbit propulsion systems.
Olyniec, Lee Michael
core +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Using Nyquist or Nyquist-Like Plot to Predict Three Typical Instabilities in DC-DC Converters
, 2012 By transforming an exact stability condition, a new Nyquist-like plot is proposed to predict occurrences of three typical instabilities in DC-DC converters.
Al-Mothafar +24 more
core +1 more source