Results 31 to 40 of about 310,780 (254)

Comparative Study between High and Low Inferior Mesenteric Artery Ligation in Laparoscopic Total Mesorectal Excision in Rectal Cancer Patients [PDF]

Ain-Shams Journal of Surgery
Introduction: Surgery is the primary treatment for rectal cancer, with laparoscopy improving visualization duringtotal mesorectal excision (TME). There are two techniques for ligating the inferior mesenteric artery (IMA): highligation at its aortic ...
Haitham Omar, Amr El Shayeb, Eslam Abdel Rasoul, Ahmed Khalifa, Mohamed Elbarmelgi   +4 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Crossotomy vs crossectomy for saphenous vein sparing surgery in patients with varicose veins due to ostial incontinence: protocol for double blind, multicenter, randomized trial

Veins and Lymphatics
Double‑blind/multicenter/randomized trial protocol. Eligibility criteria: age 18-70 yrs; C2-C5 leg varices secondary to the Great Saphenous Vein (GSV) incontinence; GSV size 6-10mm, at 10cm from the Saphenous-Femoral Junction (SFJ); ostial reflux ...
Eugenio Martelli, Laura Capoccia, Giovanni Sotgiu, Laura Saderi, Mariangela Valentina Puci, Piero Modugno, Sergio Furgiuele, Vincenzo Aversano, Salvatore De Vivo, Luca Iorio, Allegra Rosa Martelli, Stefano Ricci   +11 more
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Anastomotic leak after minimally invasive anterior resection for rectal cancer with high versus low ligation of the inferior mesenteric artery: a study protocol for a multicentre randomized clinical trial

Trials, 2022
Background Although many efforts have been made to decrease the incidence of anastomotic leak (AL), it remains one of the most serious complications of rectal cancer surgery.
Soo Young Lee, Sohyun Kim, Gyung Mo Son, Hye Jin Kim, Soo Yeun Park, Jun Seok Park, Chang Hyun Kim, Gi Won Ha, Kyung-Ha Lee, Jin Soo Kim, Ki Beom Bae, Sung Uk Bae, Sung Il Kang, Korean ColoRectal surgeOn Study group of the Southern province (K-CROSS)   +13 more
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

COMPARISON OF THE HIGH VEIN LIGATION EXTENDEN VEIN LIGATION PROCEDURE IN VARICOCELE SURGERY

Urology Research and Practice, 2019
-
K. BAYKAL, E. KARAŞEN, S. ALBAYRAK, C. ŞAHİN, B. ÖZBİLEK, Y. ÖNOL   +5 more
doaj   +2 more sources