High Mobility Group Box 1 Expression in Oral Inflammation and Regeneration
Frontiers in Immunology, 2020 High mobility group box 1 (HMGB1) is a non-histone DNA-binding protein of about 30 kDa. It is released from a variety of cells into the extracellular milieu in response to inflammatory stimuli and acts on specific cell-surface receptors, such as ...
Keisuke Yamashiro +10 more
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LPS Primes Brain Responsiveness to High Mobility Group Box-1 Protein
Pharmaceuticals, 2021 High mobility group box (HMGB)1 action contributes to late phases of sepsis, but the effects of increased endogenous plasma HMGB1 levels on brain cells during inflammation are unclear.
Verena Peek +11 more
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Mesenchymal-epithelial signalling in tumour microenvironment: role of high-mobility group Box 1. [PDF]
, 2016 Glucose deprivation, hypoxia and acidosis are characteristic features of the central core of most solid tumours. Myofibroblasts are stromal cells present in many such solid tumours, including those of the colon, and are known to be involved in all stages
A Chitanuwat +52 more
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High mobility group box 1 in diabetic nephropathy
Experimental and Therapeutic Medicine, 2017 Type 2 diabetes (T2D) is a complex disorder caused by the combined effects of genetic inheritance and environmental factors. The abnormal secretion of albumin via urine is the characteristic feature of a diabetic nephropathy (DN) patient. Moreover, the detection of this observable characteristic feature of DN is quite late.
Shi, Haitao +5 more
openaire +3 more sources
High Mobility Group Box-1 and Blood–Brain Barrier Disruption
Cells, 2020 Increasing evidence suggests that inflammatory responses are involved in the progression of brain injuries induced by a diverse range of insults, including ischemia, hemorrhage, trauma, epilepsy, and degenerative diseases.
Masahiro Nishibori +3 more
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Molecular isoforms of high-mobility group box 1 are mechanistic biomarkers for epilepsy [PDF]
, 2017 Approximately 30% of epilepsy patients do not respond to antiepileptic drugs, representing an unmet medical need. There is evidence that neuroinflammation plays a pathogenic role in drug-resistant epilepsy. The high-mobility group box 1 (HMGB1)/TLR4 axis
Alapirtti, Tiina +17 more
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From human Megakaryocytes to platelets: Effects of aspirin on high-mobility group Box 1/receptor for advanced glycation end products axis [PDF]
, 2018 Platelets (PLTs) are the major source of high-mobility group box 1 (HMGB1), a protein that is involved in sterile inflammation of blood vessels and thrombosis.
Alessandra Zicari +9 more
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High mobility group box 1 complexed with heparin induced angiogenesis in a matrigel plug assay [PDF]
, 2009 Angiogenesis involves complex processes mediated by several factors and is associated with inflammation and wound healing. High mobility group box 1 (HMGB1) is released from necrotic cells as well as macrophages and plays proinflammatory roles.
Liu, Keyue +4 more
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Inflammasomes: caspase-1-activating platforms with critical roles in host defense [PDF]
, 2011 Activation of the inflammatory cysteine protease caspase-1 in inflammasome complexes plays a critical role in the host response to microbial infections.
Lieselotte eVande Walle +3 more
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Renal expression and serum levels of high mobility group box 1 protein in lupus nephritis [PDF]
, 2012 INTRODUCTION: High mobility group box 1 protein (HMGB1) is a nuclear DNA binding protein acting as a pro-inflammatory mediator following extracellular release.
Agneta Zickert +6 more
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