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High-mobility group box 1 in acute kidney injury [PDF]
Frontiers in PharmacologyAcute kidney injury (AKI) remains a major clinical concern owing to its association with elevated morbidity and mortality. The nuclear protein high-mobility group box protein 1 (HMGB1), recognized for its evolutionary conservation, has emerged as a key ...
Xuan Li +4 more
doaj +4 more sources
Urinary and serum levels of high mobility group box 1 [PDF]
Practical Laboratory Medicine, 2023 Background: High mobility group box 1 (HMGB-1) has been extensively studied in adults and to a certain extent in neonates as well. Clinical examination of neonates, especially unwell neonates soon after birth, should be minimally invasive.
Toshihiko Nakamura +7 more
doaj +4 more sources
High Mobility Group Box 1 in Human Cancer [PDF]
Cells, 2020 High mobility group box 1 (HMGB1) is an extremely versatile protein that is located predominantly in the nucleus of quiescent eukaryotic cells, where it is critically involved in maintaining genomic structure and function. During cellular stress, however,
Bernardo L. Rapoport +6 more
doaj +4 more sources
High‐Mobility Group Box‐1 and Liver Disease [PDF]
Hepatology Communications, 2018 High‐mobility group box‐1 (HMGB1) is a ubiquitous protein. While initially thought to be simply an architectural protein due to its DNA‐binding ability, evidence from the last decade suggests that HMGB1 is a key protein participating in the pathogenesis ...
Harriet Gaskell +2 more
doaj +3 more sources
High Mobility Group Box Protein-1 in Wound Repair [PDF]
Cells, 2012 High-mobility group box 1 protein (HMGB1), a member of highly conserved non-histone DNA binding protein family, has been studied as transcription factor and growth factor.
Mauro Patrone +3 more
doaj +4 more sources
Role of High-Mobility Group Box-1 in Liver Pathogenesis [PDF]
International Journal of Molecular Sciences, 2019 High-mobility group box 1 (HMGB1) is a highly abundant DNA-binding protein that can relocate to the cytosol or undergo extracellular release during cellular stress or death. HMGB1 has a functional versatility depending on its cellular location.
Huda, Nazmul +3 more
core +4 more sources
Roles of High Mobility Group Box 1 in Cardiovascular Calcification [PDF]
Cellular Physiology and Biochemistry, 2017 Calcific disease of the cardiovascular system, including atherosclerotic calcification, medial calcification in diabetes and calcific aortic valve disease, is an important risk factor for many adverse cardiovascular events such as ischemic cardiac events
Qiang Chen +3 more
doaj +3 more sources
The Role of High Mobility Group Box 1 in Ischemic Stroke [PDF]
Frontiers in Cellular Neuroscience, 2019 High-mobility group box 1 protein (HMGB1) is a novel, cytokine-like, and ubiquitous, highly conserved, nuclear protein that can be actively secreted by microglia or passively released by necrotic neurons.
Yingze Ye +6 more
doaj +3 more sources
High-Mobility Group Box 1 and Autophagy [PDF]
, 2016 High-mobility group box 1 (HMGB1) is an architectural chromosomal protein and stress sensor that plays a critical role in various physiological and pathological processes, including cell death and survival.
Kang, Rui, Tang, Daolin
core +3 more sources
High Mobility Group Box 1 Protein in Cerebral Thromboemboli [PDF]
International Journal of Molecular Sciences, 2021 High-mobility group box 1 protein (HMGB1) is a damage-associated molecular pattern (DAMP) involved in neutrophil extracellular trap (NET) formation and thrombosis. NETs are regularly found in cerebral thromboemboli. We here analyzed associated HMGB1 expression in human thromboemboli retrieved via mechanical thrombectomy from 37 stroke patients with ...
Fabian Essig +9 more
openaire +2 more sources