Renal expression and serum levels of high mobility group box 1 protein in lupus nephritis [PDF]
, 2012 INTRODUCTION: High mobility group box 1 protein (HMGB1) is a nuclear DNA binding protein acting as a pro-inflammatory mediator following extracellular release.
Agneta Zickert +6 more
core +1 more source
The Roles of High Mobility Group Box 1 in Cerebral Ischemic Injury
Frontiers in Cellular Neuroscience, 2020 High mobility group box 1 (HMGB1) is a ubiquitous nuclear protein that plays an important role in stabilizing nucleosomes and DNA repair. HMGB1 can be passively released from necrotic neurons or actively secreted by microglia, macrophages/monocytes, and ...
Xiaoyun Gou +15 more
doaj +1 more source
Liver kinase B1 inhibits smooth muscle calcification via high mobility group box 1
Redox Biology, 2021 Vascular calcification is a common pathological feature of atherosclerosis, chronic kidney disease, vascular injury, and aging. Liver kinase B1 (LKB1) plays pivotal roles in cellular processes such as apoptosis, metabolism, and cell cycle regulation.
Tianran Zhang +10 more
doaj +1 more source
Gene Expression and Localization of High-mobility Group Box Chromosomal Protein-1 (HMGB-1) in Human Osteoarthritic Cartilage [PDF]
, 2011 We investigated the expression and localization of high-mobility group box chromosomal protein-1 (HMGB-1) in human osteoarthritic (OA) cartilage in relation to the histopathological grade of cartilage destruction, and examined the role of HMGB-1 in the ...
Mori, Shuji +9 more
core +1 more source
High mobility group box 1 (HMGB1): a pivotal regulator of hematopoietic malignancies
Journal of Hematology & Oncology, 2020 High mobility group box 1 (HMGB1) is a nonhistone chromatin-associated protein that has been widely reported to play a pivotal role in the pathogenesis of hematopoietic malignancies.
Shunling Yuan +4 more
doaj +1 more source
High mobility group box 1 protein in the central nervous system
Journal of Medical Science, 2014 High-mobility group box 1 protein (HMGB1) is a multifunctional protein originally identified as a nuclear transcription modifier. Two pathways are leading to HMGB1 release to the extracellular space i.e.
Norbert Wąsik +3 more
doaj +1 more source
NQO1 targeting prodrug triggers innate sensing to overcome checkpoint blockade resistance [PDF]
, 2019 Lack of proper innate sensing inside tumor microenvironment (TME) limits T cell-targeted immunotherapy. NAD(P)H:quinone oxidoreductase 1 (NQO1) is highly enriched in multiple tumor types and has emerged as a promising target for direct tumor-killing ...
Boothman, David A. +10 more
core +1 more source
Usefulness of High Mobility Group Box 1 Protein as a Plasma Biomarker in Patient with Peripheral Artery Disease [PDF]
, 2014 Atherosclerosis is often associated with chronic vascular inflammation. High-mobility group box 1 protein (HMGB1) plays various roles, not only as a transcriptional regulatory factor in the nucleus, but also as an inflammatory mediator.
Nishibori, Masahiro +2 more
core +1 more source
Potential significance of high-mobility group protein box 1 in cerebrospinal fluid
Heliyon, 2023 High-mobility group protein box 1 (HMGB1) is a cytokine with multiple functions (according to its subcellular location) that serves a marker of inflammation.
Zhiwu Wu, Liping Liang, Qianliang Huang
doaj +1 more source
High-Mobility Group Box 1, Oxidative Stress, and Disease [PDF]
Antioxidants & Redox Signaling, 2011 Oxidative stress and associated reactive oxygen species can modify lipids, proteins, carbohydrates, and nucleic acids, and induce the mitochondrial permeability transition, providing a signal leading to the induction of autophagy, apoptosis, and necrosis.
Daolin, Tang +3 more
openaire +2 more sources