Results 41 to 50 of about 559,451 (298)

High Mobility Group Box 1 Protein Induction by Mycobacterium Bovis BCG

Mediators of Inflammation, 2007
High mobility group box 1 protein (HMGB1), a nuclear protein, is a critical cytokine that mediates the response to infection, injury, and inflammation.
Péter Hofner, György Seprényi, András Miczák, Krisztina Buzás, Zsófia Gyulai, Katalin F. Medzihradszky, Ari Rouhiainen, Heikki Rauvala, Yvette Mándi   +8 more
doaj   +1 more source

Evaluation of high mobility group box 1 protein as a presurgical diagnostic marker reflecting the severity of acute appendicitis. [PDF]

, 2012
RIGHTS : This article is licensed under the BioMed Central licence at http://www.biomedcentral.com/about/license which is similar to the 'Creative Commons Attribution Licence'.
Chi, Junmeng, Gong, Jianping, Guo, Hui, Liu, Qi, Sun, Hang, Wang, Hongliang, Wu, Chuanxin   +6 more
core   +2 more sources

High mobility group box 1 (HMGB1) in COVID-19 [PDF]

Journal of Preventive Epidemiology, 2021
Fatemeh Kafi, Alireza Bolourian, Zahra Mojtahedi, Alireza Pouramini   +3 more
doaj   +1 more source

HMGB1-Induced Cross Talk between PTEN and miRs 221/222 in Thyroid Cancer [PDF]

, 2015
High mobility group box 1 (HMGB1) is an ubiquitous protein that plays different roles in the nucleus, cytoplasm and extra-cellular space. It is an important DAMP molecule that allows communication between damaged or tumor cells and the immune system ...
ANTONACI, Alfredo, FAGGIONI, Alberto, Fico, F., MARDENTE, Stefania, MARI, EMANUELA, MASSIMI, ISABELLA, PULCINELLI, FABIO MARIA, ZICARI, Alessandra   +7 more
core   +4 more sources

High-mobility group box-1 and its role in angiogenesis [PDF]

Journal of Leukocyte Biology, 2014
AbstractHMGB1 is an architectural chromatin-binding protein that can be released actively by activated cells or passively by dying cells and can serve as a DAMP molecule to drive the pathogenesis of inflammatory and angiogenic diseases. Through TLR4 and RAGE signaling pathways, HMGB1 could regulate vascular growth in vivo and in vitro through diverse ...
Shuai, Yang, Linxinyu, Xu, Tianshu, Yang, Fang, Wang   +3 more
openaire   +2 more sources

Serum high-mobility group box 1 protein level correlates with the lowest SaO2 in patients with sleep apnea: a preliminary study

Brazilian Journal of Otorhinolaryngology, 2022
Introduction: Serum level of high-mobility group box 1 protein is reportedly correlated with the severity of obstructive sleep apnea. Objective: We tried to evaluate the possibility of using the serum high-mobility group box 1 protein level as a biologic
Hyun Jin Min, Joon Soon Park, Kyung Soo Kim, Miran Kang, Ju Hee Seo, Joo-Heon Yoon, Chang-Hoon Kim, Hyung-Ju Cho   +7 more
doaj   +1 more source

A novel high mobility group box 1 neutralizing chimeric antibody attenuates drug-induced liver injury and postinjury inflammation in mice [PDF]

, 2016
Acetaminophen (APAP) overdoses are of major clinical concern. Growing evidence underlines a pathogenic contribution of sterile postinjury inflammation in APAP‐induced acute liver injury (APAP‐ALI) and justifies development of anti‐inflammatory therapies ...
Allhorn, Amara, Andersson, Antoine, Antoine, Antoine, Antoniades, Benkhoucha, Bhaskar, Bonaldi, Duncan, Ge, Gong, Huebener, Idusogie, Jaeschke, Kang, Knezevic, Kokkola, Lawson, Liu, McLean, Nandakumar, Nose, Ostapowicz, Qin, Scaffidi, Schiraldi, Sinclair, Stutchfield, Tiller, Tsung, Venereau, Wang, Watkins, Woolbright, Yang, Yang, Yang, Yang, Yang, Yang, Zhang   +42 more
core   +2 more sources

Identification and characterization of the lamprey high-mobility group box 1 gene. [PDF]

PLoS ONE, 2012
High-mobility group box 1 (HMGB1), a highly conserved DNA-binding protein, plays an important role in maintaining nucleosome structures, transcription, and inflammation. We identified a homolog of HMGB1 in the Japanese lamprey (Lampetra japonica).
Yue Pang, Rong Xiao, Xin Liu, Qingwei Li
doaj   +1 more source

Loss of ATF3 exacerbates liver damage through the activation of mTOR/p70S6K/ HIF-1α signaling pathway in liver inflammatory injury. [PDF]

, 2018
Activating transcription factor 3 (ATF3) is a stress-induced transcription factor that plays important roles in regulating immune and metabolic homeostasis.
Jiang, Bin, Jiang, Longfeng, Ke, Bibo, Li, Changyong, Lu, Ling, Ni, Xuhao, Wang, Han, Wang, Xuehao, Zhang, Feng, Zhu, Qiang   +9 more
core   +2 more sources

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source