High‐mobility group box 1 emerges as a therapeutic target for asthma [PDF]
Immunity, Inflammation and Disease, 2023 High‐mobility group box 1 (HMGB1) is a highly conserved nonhistone nuclear protein found in the calf thymus and participates in a variety of intracellular processes such as DNA transcription, replication and repair.
Qianni Yang +4 more
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High mobility group box 1 (HMGB1) mediates nicotine-induced podocyte injury [PDF]
Frontiers in PharmacologyIntroductionCigarette smoking is a well-established risk factor for renal dysfunction. Smoking associated with renal damage bears distinct physiological correlations in conditions such as diabetic nephropathy and obesity-induced glomerulopathy.
Sayantap Datta +3 more
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Dualistic Roles of High Mobility Group Box 1 in Cancer and Inflammation [PDF]
Cancer MedicineBackground The High Mobility Group Box 1 (HMGB1) protein, a member of the HMG family, plays a crucial role in both cancer progression and inflammatory responses.
Wen Zeng +6 more
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Higher expression of high-mobility group box 1 in cholangiocarcinoma and association with cell growth, in vitro migration and invasion, and chemo-drug sensitivity [PDF]
Science ProgressObjective Cholangiocarcinoma is a lethal malignancy with an increasing incidence and mortality worldwide. Numerous studies have indicated that high-mobility group box 1 is associated with cancer progression.
Arunya Jiraviriyakul +5 more
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High Mobility Group Box 1 (HMGB1): Molecular Signaling and Potential Therapeutic Strategies [PDF]
CellsHigh Mobility Group Box 1 (HMGB1) is a highly conserved non-histone chromatin-associated protein across species, primarily recognized for its regulatory impact on vital cellular processes, like autophagy, cell survival, and apoptosis. HMGB1 exhibits dual
Sayantap Datta +3 more
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High mobility group box 1: DAMPening the danger molecule in cardiovascular disease with exercise [PDF]
Cell Stress & ChaperonesHigh mobility group box 1 (HMGB1) is a damage-associated molecular pattern (DAMP). During cellular stress, it leaves the nucleus and moves into the extracellular space, where it modulates the development of cardiovascular diseases (CVDs), a leading ...
Yu-Chieh Liao, Jorming Goh
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High mobility group box 1 in the central nervous system: regeneration hidden beneath inflammation [PDF]
Neural Regeneration ResearchHigh-mobility group box 1 was first discovered in the calf thymus as a DNA-binding nuclear protein and has been widely studied in diverse fields, including neurology and neuroscience.
Hanki Kim +6 more
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High-mobility group box 1 and cancer [PDF]
Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2010 High-mobility group box 1 protein (HMGB1), a chromatin associated nuclear protein and extracellular damage associated molecular pattern molecule (DAMP), is an evolutionarily ancient and critical regulator of cell death and survival. Overexpression of HMGB1 is associated with each of the hallmarks of cancer including unlimited replicative potential ...
Daolin, Tang +3 more
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High Mobility Group Box 1 (HMGB1): Potential Target in Sepsis-Associated Encephalopathy
Cells, 2023 Sepsis-associated encephalopathy (SAE) remains a challenge for intensivists that is exacerbated by lack of an effective diagnostic tool and an unambiguous definition to properly identify SAE patients. Risk factors for SAE development include age, genetic
Bram DeWulf +6 more
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Role of high mobility group box 1 (HMGB1) in SCA17 pathogenesis. [PDF]
PLoS ONE, 2014 Spinocerebellar ataxia type 17 (SCA17) involves the expression of a polyglutamine (polyQ) expanded TATA-binding protein (TBP), a general transcription initiation factor. TBP interacts with other protein factors, including high mobility group box 1 (HMGB1)
Li-Ching Lee +5 more
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