Results 91 to 100 of about 1,956,380 (274)

Integration of transcriptomic data in a genome-scale metabolic model to investigate the link between obesity and breast cancer

BMC Bioinformatics, 2019
Background Obesity is a complex disorder associated with an increased risk of developing several comorbid chronic diseases, including postmenopausal breast cancer.
Ilaria Granata, Enrico Troiano, Mara Sangiovanni, Mario Rosario Guarracino   +3 more
doaj   +1 more source

Structural insights into lacto‐N‐biose I recognition by a family 32 carbohydrate‐binding module from Bifidobacterium bifidum

FEBS Letters, EarlyView.
Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang, Naoki Sunagawa, Toma Kashima, Kiyohiko Igarashi, Akimasa Miyanaga, Shinya Fushinobu   +5 more
wiley   +1 more source

From trash to treasure: detecting unexpected contamination in unmapped NGS data

BMC Bioinformatics, 2019
Background Next Generation Sequencing (NGS) experiments produce millions of short sequences that, mapped to a reference genome, provide biological insights at genomic, transcriptomic and epigenomic level. Typically the amount of reads that correctly maps
Mara Sangiovanni, Ilaria Granata, Amarinder Singh Thind, Mario Rosario Guarracino   +3 more
doaj   +1 more source

Leveraging legacy codes to distributed problem solving environments: A web service approach [PDF]

, 2003
This paper describes techniques used to leverage high performance legacy codes as CORBA components to a distributed problem solving environment. It first briefly introduces the software architecture adopted by the environment.
Huang, Y, Li, M, Rana, O, Walker, D, Ward, R, Williams, P   +5 more
core  

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Computing for Perturbative QCD - A Snowmass White Paper

, 2013
We present a study on high-performance computing and large-scale distributed computing for perturbative QCD calculations.Comment: 21 pages, 5 ...
,, /Argonne, /Fermilab, /LBNL, Berkeley, /SLAC, /SLAC, /UCLA, Bauer, Christian, Bern, Zvi, Boughezal, Radja, Campbell, John, Christensen, Neil, Dixon, Lance, Gehrmann, Thomas, Hoeche, Stefan, Kanzaki, Junichi, Mitov, Alexander, Nadolsky, Pavel, Olness, Fredrick, Peskin, Michael, Petriello, Frank, Pittsburgh, /U., Pozzorini, Stefano, Reina, Laura, Siegert, Frank, Wackeroth, Doreen, Walsh, Jonathan, Williams, Ciaran, Wobisch, Markus, Zurich, /U.   +29 more
core   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Study of combining GPU/FPGA accelerators for high-performance computing [PDF]

, 2013
This contribution presents the performance modeling of a super desktop with GPU and FPGA accelerators, using OpenCL for the GPU and a high-level synthesis compiler for the FPGAs.
Braeken, An, Cornelis, Jan G, D'Hollander, Erik, da Silva Gomes, Bruno, Lemeire, Jan, Touhafi, Abdellah   +5 more
core   +1 more source