Results 101 to 110 of about 414,061 (317)
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
xLSTM-Based Urban Traffic Flow Prediction for Intelligent Transportation Governance
Applied SciencesUrban traffic congestion poses persistent challenges to mobility, public safety, and governance efficiency in metropolitan areas. This study proposes an intelligent traffic flow forecasting framework based on an extended Long Short-Term Memory (xLSTM ...
Chung-I Huang +4 more
doaj +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
High Performance Computing and Communications Panel Report
, 1992 The High Performance Computing and Communications (HPCC) Initiative was launched in 1992 by President George H.W. Bush in an effort to secure and extend U.S. leadership in advanced technologies.
PCAST Panel on High Performance Computing and Communications +2 more
core
Ensemble of rankers for efficient gene signature extraction in smoke exposure classification
BMC Bioinformatics, 2018 Background System toxicology aims at understanding the mechanisms used by biological systems to respond to toxicants. Such understanding can be leveraged to assess the risk of chemicals, drugs, and consumer products in living organisms.
Maurizio Giordano +2 more
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Analyzing and improving MPI communication performance in overcommitted virtualized systems [PDF]
, 2011 Nowadays, it is an important trend in the system domain to use the software-based virtualization technology to build the execution environments (e.g., Clouds) and serve high performance computing extra virtualization layer, the application performance ...
Xie, Xuejiao +9 more
core +1 more source
BMC Bioinformatics, 2019 Background Obesity is a complex disorder associated with an increased risk of developing several comorbid chronic diseases, including postmenopausal breast cancer.
Ilaria Granata +3 more
doaj +1 more source