Results 101 to 110 of about 1,956,380 (274)
PyCUDA and PyOpenCL: A Scripting-Based Approach to GPU Run-Time Code Generation
, 2011 High-performance computing has recently seen a surge of interest in heterogeneous systems, with an emphasis on modern Graphics Processing Units (GPUs).
Ahmed Fasih +36 more
core +1 more source
FEBS Letters, EarlyView.Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley +1 more source
21st Century Simulation: Exploiting High Performance Computing and Data Analysis [PDF]
, 2004 This paper identifies, defines, and analyzes the limitations imposed on Modeling and Simulation by outmoded paradigms in computer utilization and data analysis.
Baer, Garth D. +2 more
core
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
FEBS Letters, EarlyView.Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
wiley +1 more source
Theoretical studies on anhydride dynamic covalent bond exchange mechanisms
Communications ChemistryAnhydrides have been utilised to synthesize covalent adaptable networks (CANs), enabling the recycling of thermosets and immiscible plastic wastes due to their dynamic bond exchange properties.
Xinglong Zhang +4 more
doaj +1 more source
A Lightweight Recurrent Architecture for Robust Urban Traffic Forecasting With Missing Data
IEEE Open Journal of Intelligent Transportation SystemsReal-time traffic flow prediction plays a vital role in alleviating urban congestion and improving transportation efficiency. However, urban traffic data are often subject to sensor anomalies, missing values, and unstable model performance.
Chung-I Huang +6 more
doaj +1 more source
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
Microsoft institute for high performance computing
, 2006 An overview of the Microsoft Institute for High Performance Computing at the University of ...
Cox, SJ, Molinari, M., Takeda, K
core
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source