Results 101 to 110 of about 1,962,023 (274)
Computing for Perturbative QCD - A Snowmass White Paper
, 2013 We present a study on high-performance computing and large-scale distributed computing for perturbative QCD calculations.Comment: 21 pages, 5 ...
, +29 more
core +1 more source
Study of combining GPU/FPGA accelerators for high-performance computing [PDF]
, 2013 This contribution presents the performance modeling of a super desktop with GPU and FPGA accelerators, using OpenCL for the GPU and a high-level synthesis compiler for the FPGAs.
Braeken, An +5 more
core +1 more source
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions
FEBS Letters, EarlyView.We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva +10 more
wiley +1 more source
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Theoretical studies on anhydride dynamic covalent bond exchange mechanisms
Communications ChemistryAnhydrides have been utilised to synthesize covalent adaptable networks (CANs), enabling the recycling of thermosets and immiscible plastic wastes due to their dynamic bond exchange properties.
Xinglong Zhang +4 more
doaj +1 more source
A Lightweight Recurrent Architecture for Robust Urban Traffic Forecasting With Missing Data
IEEE Open Journal of Intelligent Transportation SystemsReal-time traffic flow prediction plays a vital role in alleviating urban congestion and improving transportation efficiency. However, urban traffic data are often subject to sensor anomalies, missing values, and unstable model performance.
Chung-I Huang +6 more
doaj +1 more source
21st Century Simulation: Exploiting High Performance Computing and Data Analysis [PDF]
, 2004 This paper identifies, defines, and analyzes the limitations imposed on Modeling and Simulation by outmoded paradigms in computer utilization and data analysis.
Baer, Garth D. +2 more
core
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source