Results 171 to 180 of about 1,956,380 (274)

Scale-up Unlearnable Examples Learning with High-Performance Computing. [PDF]

IS&T Int Symp Electron Imaging
Zhu Y, Lyngaas I, Gopalakrishnan Meena M, Koran MEI, Malin B, Moyer D, Bao S, Kapadia A, Wang X, Landman B, Huo Y.   +10 more
europepmc   +1 more source

Perspective of drug design with high-performance computing. [PDF]

Natl Sci Rev, 2021
Li Z, Li H, Yu K, Luo HB.
europepmc   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Integration of nested cross-validation, automated hyperparameter optimization, high-performance computing to reduce and quantify the variance of test performance estimation of deep learning models. [PDF]

Comput Methods Programs Biomed
Calle P, Bates A, Reynolds JC, Liu Y, Cui H, Ly S, Wang C, Zhang Q, de Armendi AJ, Shettar SS, Fu KM, Tang Q, Pan C.   +12 more
europepmc   +1 more source

High Performance Computing PP-Distance Algorithms to Generate X-ray Spectra from 3D Models. [PDF]

Int J Mol Sci, 2022
González C, Balocco S, Bosch J, de Haro JM, Paolini M, Filgueras A, Álvarez C, Pons R.   +7 more
europepmc   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

ScRNAbox: empowering single-cell RNA sequencing on high performance computing systems. [PDF]

BMC Bioinformatics
Thomas RA, Fiorini MR, Amiri S, Fon EA, Farhan SMK.   +4 more
europepmc   +1 more source

Inference-Optimized AI and High Performance Computing for Gravitational Wave Detection at Scale. [PDF]

Front Artif Intell, 2022
Chaturvedi P, Khan A, Tian M, Huerta EA, Zheng H.   +4 more
europepmc   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

High Performance Computing [PDF]

, 2016
  +4 more sources