Results 171 to 180 of about 1,962,023 (274)

Accelerating Hyperparameter Tuning in Machine Learning for Alzheimer's Disease With High Performance Computing. [PDF]

Front Artif Intell, 2021
Zhang F, Petersen M, Johnson L, Hall J, O'Bryant SE.   +4 more
europepmc   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Scale-up Unlearnable Examples Learning with High-Performance Computing. [PDF]

IS&T Int Symp Electron Imaging
Zhu Y, Lyngaas I, Gopalakrishnan Meena M, Koran MEI, Malin B, Moyer D, Bao S, Kapadia A, Wang X, Landman B, Huo Y.   +10 more
europepmc   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Integration of nested cross-validation, automated hyperparameter optimization, high-performance computing to reduce and quantify the variance of test performance estimation of deep learning models. [PDF]

Comput Methods Programs Biomed
Calle P, Bates A, Reynolds JC, Liu Y, Cui H, Ly S, Wang C, Zhang Q, de Armendi AJ, Shettar SS, Fu KM, Tang Q, Pan C.   +12 more
europepmc   +1 more source

Perspective of drug design with high-performance computing. [PDF]

Natl Sci Rev, 2021
Li Z, Li H, Yu K, Luo HB.
europepmc   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

High Performance Computing [PDF]

, 2016
  +4 more sources

ComPRePS 2.0: Enabling Massive-Scale Distributed Computing on High-Performance Computing Cluster for Histopathological Data Processing. [PDF]

Proc SPIE Int Soc Opt Eng
Kumar SKC, Paul AS, Abdelazim H, Dunklin W, Manthey D, Moskalenko O, Mimar S, Deumens E, Sarder P.   +8 more
europepmc   +1 more source

High Performance Computing PP-Distance Algorithms to Generate X-ray Spectra from 3D Models. [PDF]

Int J Mol Sci, 2022
González C, Balocco S, Bosch J, de Haro JM, Paolini M, Filgueras A, Álvarez C, Pons R.   +7 more
europepmc   +1 more source