Results 91 to 100 of about 16,252,677 (304)

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Atomic understanding of the evolutionary mechanism of fused glass densification generation during single particle scratching

Journal of Materials Research and Technology
The densification of fused glass during processing has a significant impact on the performance and application of fused glass components. However, the precise atomic mechanisms underlying densification remain elusive. In this study, we explore the atomic
Yueming Deng, Xiaoguang Guo, Hao Wang, Song Yuan, Wei Liu, Renke Kang, Shang Gao   +6 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Activity at IPT in precision engineering

, 2022
Precision Engineering is a grouping of multidisciplinary scientific and engineering techniques including dimensional metrology, high precision machine design, process technology, microengineering and nanotechnology.
Luderich, Jörg, Weck, Manfred
core   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Effect of Nanographene Water-Based Lubricant (NGWL) on Removal Behavior of Pure Copper

Lubricants
Pure copper is an important metal material in the fields of integrated circuits, mold manufacturing, and aerospace. Its excellent ductility and plasticity lead to problems such as burrs and tool wear in cutting, which poses great challenges to the ...
Ziheng Wang, Zhenjing Duan, Shuaishuai Wang, Ji Tan, Peng Bian, Jiyu Liu, Jinlong Song, Xin Liu   +7 more
doaj   +1 more source

High-precision regressors for particle physics

Scientific Reports
AbstractMonte Carlo simulations of physics processes at particle colliders like the Large Hadron Collider at CERN take up a major fraction of the computational budget. For some simulations, a single data point takes seconds, minutes, or even hours to compute from first principles. Since the necessary number of data points per simulation is on the order
Bishara, Fady, Paul, Ayan, Dy, Jennifer
openaire   +7 more sources

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Heterogeneous Wettability‐Based Construction of Two‐Phase Interfaces for Underwater Reversible Adhesion

Advanced Science
Underwater smart adhesives with switchable adhesion have attracted significant attention for applications in marine engineering and biomedical fields. However, achieving both robust adhesion and rapid on‐demand detachment in aquatic environments remains ...
Xiaokai Li, Yonghui Zhang, Yongxin Li, Jiahao Zhang, Yuheng Li, Zhengyu Li, Jianwu Wang, Yaochen Lv, Yanan Wang, Jiyu Liu, Xin Liu, Huanxi Zheng   +11 more
doaj   +1 more source