Results 81 to 90 of about 1,123,025 (269)

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Effect of Nanographene Water-Based Lubricant (NGWL) on Removal Behavior of Pure Copper

Lubricants
Pure copper is an important metal material in the fields of integrated circuits, mold manufacturing, and aerospace. Its excellent ductility and plasticity lead to problems such as burrs and tool wear in cutting, which poses great challenges to the ...
Ziheng Wang, Zhenjing Duan, Shuaishuai Wang, Ji Tan, Peng Bian, Jiyu Liu, Jinlong Song, Xin Liu   +7 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Heterogeneous Wettability‐Based Construction of Two‐Phase Interfaces for Underwater Reversible Adhesion

Advanced Science
Underwater smart adhesives with switchable adhesion have attracted significant attention for applications in marine engineering and biomedical fields. However, achieving both robust adhesion and rapid on‐demand detachment in aquatic environments remains ...
Xiaokai Li, Yonghui Zhang, Yongxin Li, Jiahao Zhang, Yuheng Li, Zhengyu Li, Jianwu Wang, Yaochen Lv, Yanan Wang, Jiyu Liu, Xin Liu, Huanxi Zheng   +11 more
doaj   +1 more source

Effect of AlF3·3H2O addition on microstructure and properties of ceramic shell for investment casting

Cailiao gongcheng
Using fused corundum powder as raw material， silica sol as a binder， and aluminum fluoride trihydrate as mullite phase conversion promoter， the slurry composition of the ceramic shell for directional solidification molding of turbine blades was designed，
LI Zhihui, ZHAO Yanjie, CHEN Xiaoyan, QI Chengkang, LAI Junhua, LU Liangliang, LI Fei   +6 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

High-precision regressors for particle physics

Scientific Reports
AbstractMonte Carlo simulations of physics processes at particle colliders like the Large Hadron Collider at CERN take up a major fraction of the computational budget. For some simulations, a single data point takes seconds, minutes, or even hours to compute from first principles. Since the necessary number of data points per simulation is on the order
Bishara, Fady, Paul, Ayan, Dy, Jennifer
openaire   +6 more sources

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

An electrocyte‐inspired moisture‐driven electricity generator for self‐sustained water electrolysis

Droplet
Harvesting electricity from ubiquitous moisture offers the promise of clean power for self‐sustained systems. Despite extensive efforts, achieving high‐power electricity generation remains challenging.
Quanmao Wei, Wenna Ge, Chenguang Lu, Zichao Yuan, Lei Yi, Yuhui Zhao, Shile Feng, Yu Sun, Lei Zhao, Yahua Liu   +9 more
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source