Results 71 to 80 of about 16,252,677 (304)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Solubility and diffusion coefficient of supercritical CO2 in polystyrene dynamic melt
e-Polymers, 2020 The solubility and diffusion coefficient of supercritical CO2 in polystyrene (PS) dynamic melt were studied by using a new constant pressure experimental device.
Wang Long, Huang Xingyuan, Wang Duyang
doaj +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Cascade: hardware for high/variable precision arithmetic [PDF]
, 1989 technical reportThe Cascade hardware architecture for high/variable precision arithmetic is described. It uses a radix-16 redundant signed-digit number representation and directly supports single or multiple precision addition, subtraction ...
Cascade hardware; Precision arithmetic +1 more
core
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Experimental study on end face grinding stability of thin-walled CFRP circular cell
Jin'gangshi yu moliao moju gongchengObjectivesCFRP circular cell honeycomb consists of thin-walled circular cells and are applied in the aerospace. It is difficult to machine the CFRP honeycomb due to its characteristics of thin walls, weak rigidity and non-continuous periodicity.
Shulong WANG +4 more
doaj +1 more source
A checking technique for high precision GPS antennas
, 2000 A practical checking technique is developed for high precision GPS antennas. This technique is designed to check whether there are any unmodelled phase centre positional errors (i.e. gross phase centre residuals) of the high precision GPS antennas.
Kam, B. B., Chong, A. K.
core +1 more source