Results 91 to 100 of about 18,916,146 (313)

Compressibility of insulin amyloid fibrils determined by X-ray diffraction in a diamond anvil cell

, 2009
Amyloid fibrils are fibrous structures that originate from the self-assembly of polypeptides. Their formation is linked to debilitating diseases associated with protein misfolding, including Alzheimer's disease and type-II diabetes.
Cabrera, Raul Quesada, McMillan, Paul F., Meersman, Filip, Dmitriev, Vladimir, Quesada Cabrera, Raúl, 47th Meeting of the European-High-Pressure-Research-Group (EHPRG 47)   +5 more
core   +1 more source

Application of machine learning for nanodiamonds shape and surface classification based on X-ray pattern analysis

Scientific Reports
Three Machine Learning algorithms, namely Random Forest, Neural Networks and Extreme Gradient Boosting, were applied to recognize the shape and surface structure of diamond nanoparticles from powder diffraction data.
Kazimierz Skrobas, Kamila Stefańska-Skrobas, Svitlana Stelmakh, Stanisław Gierlotka, Bogdan Palosz   +4 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

High‐Pressure Entry into Platencin

Angewandte Chemie, 2008
Contains fulltext : 72278.pdf (Publisher’s version ) (Open Access)
Waalboer, D.C.J., Schaapman, M.C., Delft, F.L. van, Rutjes, F.P.J.T.   +3 more
openaire   +3 more sources

The optimal substrate choice for effective biosensors based on THz metasurfaces

Scientific Reports
This article explores the impact of substrate choice on the sensitivity of sensors that utilize metallic terahertz metasurfaces as the actuating element.
Pradeep Tiwari, Deepak Kala, Maciej Sakowicz   +2 more
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

CHRONOBIOLOGY OF HIGH BLOOD PRESSURE.

Scripta medica, 2007
BIOCOS, the project aimed at studying BIOlogical systems in their COSmos, has obtained a great deal of expertise in the fields of blood pressure (BP) and heart rate (HR) monitoring and of marker rhythmometry for the purposes of screening, diagnosis, treatment, and prognosis.
Cornélissen G, Halberg F, Bakken EE, Wang Z, TARQUINI, ROBERTO, PERFETTO, FEDERICO, LAFFI, GIACOMO, Maggioni C, Kumagai Y, Homolka P, Havelková A, Dušek J, Svačinová H, Siegelová J, Fišer B.   +14 more
openaire   +4 more sources

Recent advances in synthesis, structure, and properties of binary and ternary transition metal phosphides [PDF]

Matter and Radiation at Extremes
Transition metal phosphides exhibit diverse crystal structures and intriguing physical properties, including superconductivity and magnetism. Despite extensive studies, obtaining a comprehensive understanding of the synthesis methods, structural ...
Xinyue Wang, Xin Yang, Liyunxiao Wu, Jun Deng, Qingyang Hu, Huiyang Gou   +5 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source