Results 71 to 80 of about 19,853,280 (266)

Redox reactions in subducted CaCO3–Fe–SiO2 as a potential source of superdeep diamond inclusions

Scientific Reports
CaCO3 is one of the most abundant carbonates at the Earth’s surface. It is transported into the mantle in substantial quantities via subducted slabs and participates in the deep mantle carbon cycle along with other mantle materials.
Mengqi Guo, Xinyang Li, Zhu Mao, Fangfei Li, Liang Li, Qiang Zhou   +5 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

High pressure amorphization of solid furan

, 2000
High pressure amorphization of solid ...
Vincenzo Schettino, Roberto Bini, Mario Santoro, Matteo Ceppatelli   +3 more
core  

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

The optimal substrate choice for effective biosensors based on THz metasurfaces

Scientific Reports
This article explores the impact of substrate choice on the sensitivity of sensors that utilize metallic terahertz metasurfaces as the actuating element.
Pradeep Tiwari, Deepak Kala, Maciej Sakowicz   +2 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Application of machine learning for nanodiamonds shape and surface classification based on X-ray pattern analysis

Scientific Reports
Three Machine Learning algorithms, namely Random Forest, Neural Networks and Extreme Gradient Boosting, were applied to recognize the shape and surface structure of diamond nanoparticles from powder diffraction data.
Kazimierz Skrobas, Kamila Stefańska-Skrobas, Svitlana Stelmakh, Stanisław Gierlotka, Bogdan Palosz   +4 more
doaj   +1 more source

Solvent Exchange and Complex Formation Reactions of Pd(II) in Aqueous Solution. Mechanistic Information from High Pressure Studies

, 1990
High pressure NMR and stopped-flow techniques have been employed to study a series of water exchange and complex formation reactions of Pd(II) outlined in (1) and (2).
Elding, Lars Ivar, van Eldik, Rudi, Merbach, Andre E., Helm, L, Hellquist, Björn,, Helm, Lothar, Merbach, A.E, Hellquist, Björn, van Eldik, R, Ducommun, Y, Ducommun, Yves, Elding, L.I, Elding, Lars Ivar,, Helm, Lothar,, Merbach, Andre E.,, Ducommun, Yves,, Lund University., van Eldik, Rudi,   +17 more
core   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source