Results 281 to 290 of about 1,272,243 (389)

The Novel Dual GIP and GLP‐1 Receptor Agonist Tirzepatide Attenuates Colon Cancer Development by Regulating Glucose Metabolism

Advanced Science, EarlyView.
Tirzepatide, a dual GIP/GLP‐1 receptor agonist for diabetes, suppresses colorectal cancer growth by targeting glucose metabolism. It inhibits cancer cell proliferation, promotes apoptosis, and induces tumor regression. It reduces glucose uptake and destabilizes HIF‐1α for degradation to downregulate PFKFB3/PFK‐1 enzymes, thus contributing to the ...
Yikai Zhang, Yi Xie, Shenglong Xia, Xinnuo Ge, Jiaying Li, Fang Liu, Fan Jia, Shengyao Wang, Qiao Zhou, Menghan Gao, Weihuan Fang, Chao Zheng   +11 more
wiley   +1 more source

Separation of Diisopropylnaphthalene Isomers: Advances and Challenges in the Petrochemical Industry. [PDF]

ACS Omega
Zheng M, Li D, Wang Z, Sun Z, Qian J, Zhang Z, Chen Q.   +6 more
europepmc   +1 more source

MEMS Mass Spectrometers: the Next Wave of Miniaturization [PDF]

, 2015
Syms, R, Wright, S
core   +1 more source

SIRT4 Promotes Pancreatic Cancer Stemness by Enhancing Histone Lactylation and Epigenetic Reprogramming Stimulated by Calcium Signaling

Advanced Science, EarlyView.
As a downstream target of α2δ1‐mediated calcium signaling, SIRT4 serves as an oncogene to promote the stemness of pancreatic cancer via deacetylating ENO1 directly at K358, leading to attenuated ENO1's RNA‐binding capacity, enhanced glycolytic substrate 2‐PG binding and robust glycolytic activity to increase the level of lactate that induce histone ...
Mengzhu Lv, Xiaodan Yang, Congcong Xu, Qingru Song, Hailian Zhao, Tianjiao Sun, Jingtao Liu, Yuan Zhang, Guogui Sun, Yuanchao Xue, Zhiqian Zhang   +10 more
wiley   +1 more source

Analysis of Assessment Methods for Detecting Nicotine Residue and Its Impact on Humans: A Systematic Review. [PDF]

Int J Environ Res Public Health
Almassi AA, Oliver BGG, Smith SM.
europepmc   +1 more source

Integrative Multi‐Omics and Routine Blood Analysis Using Deep Learning: Cost‐Effective Early Prediction of Chronic Disease Risks

Advanced Science, EarlyView.
Omicsformer, a deep learning model, integrates multi‐omics and routine blood data to accurately predict risks for nine chronic diseases, including cancer and cardiovascular conditions. Validated using large scale clinical data, it reveals early risk trajectories, advancing personalized medicine and offering a cost‐effective, community‐based solution ...
Zhibin Dong, Pei Li, Yi Jiang, Zhihan Wang, Shihui Fu, Hebin Che, Meng Liu, Xiaojing Zhao, Chunlei Liu, Chenghui Zhao, Qin Zhong, Chongyou Rao, Siwei Wang, Suyuan Liu, Dayu Hu, Dongjin Wang, Juntao Gao, Kai Guo, Xinwang Liu, En Zhu, Kunlun He   +20 more
wiley   +1 more source

Recent Advances in Bioanalysis of Cephalosporins Toward Green Sample Preparation. [PDF]

J Sep Sci
Kousi M, Kalogiouri NP, Samanidou VF.
europepmc   +1 more source

Ultra‐low LOD H2O2 Sensor Based on Synergistic Nernst Potential Effect

Advanced Science, EarlyView.
Due to the synergistic effect of ENernst,H2O2${E}_{\mathrm{Nernst},\ {\mathrm{H}}_{2}{\mathrm{O}}_{2}}$ and ENernst,H+${E}_{\mathrm{Nernst},\ {\mathrm{H}}^{+}}$, the proposed sensors in this study can achieve ultralow H2O2 detection limit as low as 1.8 × 10−12 M based on the stacked PEDOT: BTB/PEDOT: PSS semiconducting layer.
Zhaoqun Wang, Wen Gao, Xiaorong Niu, Yuhang Liu, Zichen Jin, Fan Zhang, Zhengdong Cheng, Xiaoning Jiang, Wendong Zhang, Ting Wang, Jianlong Ji, Xiaojie Chai, Shengbo Sang   +12 more
wiley   +1 more source

Archaeal Lipids: Extraction, Separation, and Identification via Natural Product Chemistry Perspective. [PDF]

Int J Mol Sci
Li T, Luo Y, Liu C, Lu X, Feng B.
europepmc   +1 more source

High‐Viability Circulating Tumor Cells Sorting From Whole Blood at Single Cell Level Using Laser‐Induced Forward Transfer‐Assisted Microfiltration

Advanced Science, EarlyView.
A laser‐induced forward transfer‐assisted microfiltration system is developed for single rare cell sorting from undiluted whole blood. The isolated cell has a high viability, enabling successful ex vivo cell culture and efficient single‐cell RNA sequencing.
Qingmei Xu, Yuntong Wang, Songtao Dou, Yang Xu, Zhenhe Xu, Han Xu, Yi Zhang, Yanming Xia, Ying Xue, Hang Li, Xiao Ma, Kunlong Zhang, Huan Wang, Fengzhou Ma, Qi Wang, Bei Li, Wei Wang   +16 more
wiley   +1 more source