Results 111 to 120 of about 19,407,241 (210)

Gigahertz harmonic mode-locking with multi-watt sub-60-fs pulses in a Mamyshev oscillator

High Power Laser Science and Engineering
The Mamyshev oscillator (MO) is well-known for its high modulation depth, which provides an excellent platform for achieving both high average power and short pulse durations.
Feihong Qiao, Ze Li, Ning Jia, Xiangtong Zhai, Hao Liang, Zhiguo Lv   +5 more
doaj   +1 more source

A role for eIF5A in translational control of stress‐inducible proteins in multiple myeloma cell lines

Molecular Oncology, EarlyView.
Loss of eIF5A rewires thapsigargin‐mediated endoplasmic reticulum stress responses in multiple myeloma cells by selective translation of mRNA transcripts, consequently dampening thapsigargin‐induced unfolded protein response (UPR) activation and shifting the balance from induction of apoptosis toward cell survival and proliferation.
Demi Both, Ingrid A. M. Derks, Raphaël Vanleyssem, Marine Leclercq, Najla El Hachem, Pierre Close, Eric Eldering, Marco Vincent Haselager   +7 more
wiley   +1 more source

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

Molecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira, Ana Teixeira‐Marques, Rui Freitas, João A Carvalho, Sara Monteiro‐Reis, Giorgio I. Russo, Rui Henrique, Carmen Jerónimo   +7 more
wiley   +1 more source

Performing MHz-Level Repetition Rate Tuning for Coherent Dual-Microcomb Interferometry

Micromachines
The high-repetition-rate dual-microcomb interferometry, characterized by its high precision, rapid measurement speed, and ease of integration, shows significant promise in applications such as precision spectroscopy and high-speed precision ranging.
Enqi Yan, Mingliang Peng, Jian Tang, Jiyuan Huang, Donglai Tian, Suyang Liu, Zhijun Meng, Xianbin Li, Lingxiao Zhu, Shuhua Yan, Guochao Wang   +10 more
doaj   +1 more source

Ultrafast Laser Systems for High Repetition Rate FELs

, 2023
We describe the ultrafast laser systems which are currently planned, under construction or installed to operate the high repetition rate free electron laser facilities FLASH and European ...
Swiderski, Angad, kazemi, mehdi, Zheng, Jiaan, Große-Wortmann, Uwe, Mohr, Christian, Lang, Tino, Hartwell, Samuel, Tajalli Seifi, Ayhan, Pressacco, Federico, yi, hua, y, jiang, Hariton, Victor, Cirmi, Giovanni, Tuennermann, Henrik, Cankaya, Hueseyin, Chen, Lin, Mahnke, Christoph, Tavakol, Hamed, Ahmed, Areeb, Akcaalan, Oender, Heyl, Christoph, Alisauskas, Skirmantas, Hartl, Ingmar, Seidel, Marcus, Darvill, John   +24 more
core  

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

High repetition rate fiber lasers [PDF]

, 2009
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 2009.Cataloged from PDF version of thesis.Includes bibliographical references (p.
Chen, Jian, Ph. D. Massachusetts Institute of Technology
core  

Liquid crystal lasers: overcoming repetition rate limitations

, 2018
Liquid crystal lasers have advantageous features including continuous wavelength tuning at low cost. Although many potential applications have been highlighted, use of these lasers is not widespread, partially due to performance limitations.
Normand, Margaret, Hands, Philip; id_orcid, Can, Chi, School of Engineering, UoE (The University of Edinburgh) : Student, Chen, Peigang, Hands, Philip   +6 more
core   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source