Results 131 to 140 of about 193,097 (307)

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Performing MHz-Level Repetition Rate Tuning for Coherent Dual-Microcomb Interferometry

Micromachines
The high-repetition-rate dual-microcomb interferometry, characterized by its high precision, rapid measurement speed, and ease of integration, shows significant promise in applications such as precision spectroscopy and high-speed precision ranging.
Enqi Yan, Mingliang Peng, Jian Tang, Jiyuan Huang, Donglai Tian, Suyang Liu, Zhijun Meng, Xianbin Li, Lingxiao Zhu, Shuhua Yan, Guochao Wang   +10 more
doaj   +1 more source

Influence of Heat Accumulation on Morphology Debris Deposition and Wetting of LIPSS on Steel upon High Repetition Rate Femtosecond Pulses Irradiation. [PDF]

Materials (Basel), 2022
Florian C, Fuentes-Edfuf Y, Skoulas E, Stratakis E, Sanchez-Cortes S, Solis J, Siegel J.   +6 more
europepmc   +1 more source

Laser pulse control of a Q-switched Nd:YVO₄ bounce geometry laser using a secondary cavity

Pulsed laser operation is desirable for a wide range of applications such as laser micromachining in industrial manufacturing and laser marking for product identification. In these cases it is beneficial to have flexibility in the parameters of the laser
Damzen, M., Shardlow, P.C., Arbabzadah, E.   +2 more
core  

Optimization of the high repetition rate all-fiber two-stage ytterbium-doped fiber amplifier

, 2011
Based on the technique of master oscillator power amplifier (MOPA), a two-stage ytterbium-doped fiber amplifier (YDFA) with all-fiber structure is theoretically simulated.
Gao Cunxiao, DongLijun, SunChuandong, GaoCunxiao, YunJian, ZhuShaolan   +5 more
core  

100W single mode single polarization picosecond ytterbium doped fibre MOPA frequency doubled to 530nm

, 2009
High average power laser sources operating in the picosecond (ps) regime are useful for a wide range of applications including frequency-doubling and pumping of OPOs.
Lin, Dejiao, Hayes, J., K. K. Chen, Richardson, D.J., Chen, K.K., Malinowski, A., Alam, S.-U., Shaif-ul Alam, D. J. Richardson, D. Lin, J. R. Hayes, A. Malinowski, Hayes, J.R.   +12 more
core   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Nonlinear thermal lensing of high repetition rate ultrafast laser light in plasmonic nano-colloids. [PDF]

Nanophotonics, 2022
Agiotis L, Meunier M.
europepmc   +1 more source

High-power, high repetition rate, tunable, ultrafast vortex beam in the near-infrared

, 2017
We report on experimental demonstration of high power, ultrafast, high repetition rate vortex beam source tunable in the near-IR wavelength range. Based on single-pass optical parametric generation of Yb-fiber laser of vortex order lp=1 in a 50 mm long ...
G. K. Samanta (14410062), A. Aadhi (16655091)   +1 more
core   +1 more source