Results 121 to 130 of about 19,407,241 (210)

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Fundamentally mode-locked Yb³⁺ doped glass waveguide lasers with repetition rate of up to 15.2 GHz

, 2013
Ultrafast lasers with multi-GHz repetition rates can have applications in areas such as biophotonics, optical frequency metrology, optical sampling, optical communications and as astro-combs.
Shepherd, D.P., Lagatsky, A.A., Sibbett, W., Choudhary, Amol, Brown, C.T.A., Pradeesh, Kannan, C. T. A. Brown, D. P. Shepherd, A. Choudhary, W. Sibbett, A. A. Lagatsky, K. Pradeesh   +11 more
core   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Wavefront sensing at a high-repetition-rate X-ray free-electron laser

Journal of Synchrotron Radiation
Wavefront characterization is essential for diagnosing, interpreting and mitigating performance limitations at X-ray free-electron lasers (XFELs).
Trey Guest, Patrik Vagovič, Luigi Adriano, Johan Bielecki, Sarlota Birnsteinova, Rita Graceffa, Jayanath Koliyadu, Kaye Morgan, Hiiro Moriyama, Daniel Mosko, Grant van Riessen, Kristian Sabol, Tokushi Sato, Peter Szeles, Zane Taylor, Jozef Uličný, Richard Bean, Adrian P. Mancuso, Brian Abbey   +18 more
doaj   +1 more source

High fundamental-repetition-rate bound solitons in carbon nanotube-based fiber lasers

, 2015
© 2015 IEEE.We demonstrate bound solitons formation with a high fundamental-repetition-rate of 211.8 MHz from an all-fiber linear-configuration mode-locked laser incorporating a carbon-nanotube-based saturable absorber for the first time.
HH Liu (4699540), Kin Kee Chow (23880933)   +1 more
core  

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer

Molecular Oncology, EarlyView.
New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau, Daniel Pincher, Clifford Young, Nicholas Chappell, Noor A. Lokman, Parul Mittal, Leigh Donnellan, Martin K. Oehler, Doug A. Brooks, Peter Hoffmann   +9 more
wiley   +1 more source

High repetition rate ultrashort pulse micromachining with fiber lasers

, 2022
Paper FThC1Despite its advantages with respect to precision, ultrashort pulse micromachining often suffers from a low processing speed. We will discuss the opportunities for high repetition rate and high average power ultrafast fiber lasers to overcome ...
Nolte, S., Ancona, A., Tünnermann, A., Döring, S., Limpert, J.   +4 more
core  

The impact of leukocyte‐associated RNA retention on platelet RNA‐based cancer detection

Molecular Oncology, EarlyView.
Platelets carry RNA signals that may help detect cancer, but platelet samples can also retain RNA from white blood cells. We found that this retained white blood cell signal did not significantly affect machine learning cancer classification, suggesting that the cancer‐related RNA signal in platelets is largely independent of leukocyte‐associated RNA ...
Michał Sieczczyński, Krzysztof Pastuszak, Anna Samelak‐Czajka, Zuzanna Cemka, Paulina Jackowiak, Tomasz Stefaniak, Sylwia Łapińska‐Szumczyk, Jacek Jassem, Anna J. Żaczek, Matthew T. Rondina, Myron G. Best, Sjors G. J. G. In 't Veld, Anna Supernat   +12 more
wiley   +1 more source