Results 61 to 70 of about 20,980,761 (308)

High-Resolution Terahertz Spectrometer [PDF]

IEEE Journal of Selected Topics in Quantum Electronics, 2011
Terahertz time-domain spectroscopy (THz-TDS) based on high-speed asynchronous optical sampling (ASOPS) with two offset-locked GHz femtosecond lasers requires no mechanical time-delay scanner. Consequently, measurements with 1-GHz frequency resolution are performed at intrinsically high scan rates in the multikilohertz range. This is at least one order,
Klatt, Gregor, Gebs, Raphael, Schäfer, Hanjo, Nagel, Michael, Janke, Christof, Bartels, Albrecht, Dekorsy, Thomas   +6 more
openaire   +2 more sources

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

BET inhibition unmasks a targetable glycolytic dependency through a HIF1α stabilization and driven transcriptional program in a defined subset of triple-negative breast Cancer

Cell Death Discovery
Triple-negative breast cancer (TNBC) is characterized by transcriptional and metabolic heterogeneity, which influences its response to therapeutics. Epigenetic drugs such as Bromodomain and Extra-Terminal domain inhibitors (BETi) are no exception to this
Teresa Rossi, Egidio Iorio, Mattea Chirico, Maria Elena Pisanu, Federica Torricelli, Alessia Ciarrocchi, Mariaelena Pistoni   +6 more
doaj   +1 more source

Structural analysis of nanocrystals by pair distribution function combining electron diffraction with crystal tilting

IUCrJ
As an important characterization method, pair distribution function (PDF) has been extensively used in structural analysis of nanomaterials, providing key insights into the degree of crystallinity, atomic structure, local disorder etc.
Linshuo Guo, Shitao Wu, Zhengyang Zhou, Yanhang Ma   +3 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Kinematical and dynamical properties of recently discovered bulge and disc star clusters with WINERED

Astronomy & Astrophysics
Context. Galactic globular clusters are a very important tool in explaining the characteristics of the Milky Way. Therefore it is essential to determine the kinematical and dynamical properties of the new star cluster candidates, especially at the low ...
Petralia Ilaria, Minniti Dante, Fernández-Trincado José G., Matsunaga Noriyuki, Taniguchi Daisuke, Saroon Sasi, Garro Elisa R., Sameshima Hiroaki, Otsubo Shogo, Sarugaku Yuki, Takeuchi Tomomi   +10 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source