Results 71 to 80 of about 2,028,180 (267)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

High-Speed Smart Camera with High Resolution

EURASIP Journal on Embedded Systems, 2007
High-speed video cameras are powerful tools for investigating for instance the biomechanics analysis or the movements of mechanical parts in manufacturing processes. In the past years, the use of CMOS sensors instead of CCDs has enabled the development of high-speed video cameras offering digital outputs, readout flexibility, and lower manufacturing ...
Romuald Mosqueron, Julien Dubois, Michel Paindavoine   +2 more
openaire   +2 more sources

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

PFAS residue analysis in fish and fish feed by applying a modified QuEChERS method in combination with LC-HRMS detection

Emerging Contaminants
A targeted method for the quantitative determination of PFAS residues in fish feed and marine aquaculture fish species was developed and validated in the current study.
Ourania Koloka, Vasiliki Boti, Dimitra Hela, Triantafyllos Albanis, Ioannis Konstantinou   +4 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Allosteric coupling between G‐protein binding and extracellular ligand binding sites in GPR52 revealed by 19F‐NMR and cryo‐electron microscopy

MedComm, 2023
Yanliu Fan, Xi Lin, Benxun Pan, Bo Chen, Dongsheng Liu, Kurt Wüthrich, Fei Xu   +6 more
doaj   +1 more source

In situ electron diffraction tomography study of the successive phase transitions in LaTaO4 nanocrystals

Nature Communications
The ferroelectric oxide LaTaO4, with a layered perovskite-related structure, exhibits a reversible temperature-dependent phase transition between its low-temperature paraelectric and high-temperature ferroelectric states.
Shitao Wu, Changhan Peng, Wuzong Zhou, Finlay D. Morrison, Grant W. Howieson, Yanhang Ma   +5 more
doaj   +1 more source

Untwisting the Caenorhabditis elegans embryo

eLife, 2015
The nematode Caenorhabditis elegans possesses a simple embryonic nervous system with few enough neurons that the growth of each cell could be followed to provide a systems-level view of development.
Ryan Patrick Christensen, Alexandra Bokinsky, Anthony Santella, Yicong Wu, Javier Marquina-Solis, Min Guo, Ismar Kovacevic, Abhishek Kumar, Peter W Winter, Nicole Tashakkori, Evan McCreedy, Huafeng Liu, Matthew McAuliffe, William Mohler, Daniel A Colón-Ramos, Zhirong Bao, Hari Shroff   +16 more
doaj   +1 more source