Results 1 to 10 of about 231,672 (215)
High-Resolution Native Mass Spectrometry [PDF]
Chemical Reviews, 2021 Native mass spectrometry (MS) involves the analysis and characterization of macromolecules, predominantly intact proteins and protein complexes, whereby as much as possible the native structural features of the analytes are retained. As such, native MS enables the study of secondary, tertiary, and even quaternary structure of proteins and other ...
Sem Tamara +2 more
openaire +4 more sources
High Resolution Mass Spectrometry [PDF]
Analytical Chemistry, 2012 ■ CONTENTS Mass Resolution, Mass Resolving Power 708 Mass Resolution and Accuracy 708 Time-of-Flight Mass Analyzers 708 Orthogonal Acceleration (see ref 13) 709 Reflectron/Multipass TOF 709 Recent Advances in TOF Mass Analyzers 709 Selected Applications 710 Fourier Transform Mass Analyzers 710 Common Features of Fourier Transform Mass Analyzers 710 Ion
Feng, Xian +2 more
openaire +4 more sources
Resolution Ladder for High-Resolution Mass Spectrometry [PDF]
Analytical Chemistry, 2017 High-resolution mass spectrometry has become a key technology in life sciences. Since it is often unfeasible to find pairs of analytes with an appropriate mass difference to actually quantify the resolution experimentally, resolution is usually calculated from the shape of a single mass peak.
Matthias Schittmayer +1 more
openaire +2 more sources
HIGH RESOLUTION MASS SPECTROMETRY IN LIPIDOMICS [PDF]
Mass Spectrometry Reviews, 2020 The boost of research output in lipidomics during the last decade is tightly linked to improved instrumentation in mass spectrometry. Associated with this trend is the shift from low resolution—toward high‐resolution lipidomics platforms. This review article summarizes the state of the art in the lipidomics field with a particular focus on the merits ...
Thomas Züllig, Harald C. Köfeler
openaire +2 more sources
High resolution laser mass spectrometry bioimaging [PDF]
Methods, 2016 Mass spectrometry imaging (MSI) was introduced more than five decades ago with secondary ion mass spectrometry (SIMS) and a decade later with laser desorption/ionization (LDI) mass spectrometry (MS). Large biomolecule imaging by matrix-assisted laser desorption/ionization (MALDI) was developed in the 1990s and ambient laser MS a decade ago.
Kermit K, Murray +2 more
openaire +2 more sources
Intact MicroRNA Analysis Using High Resolution Mass Spectrometry [PDF]
Journal of the American Society for Mass Spectrometry, 2013 MicroRNAs (miRNAs) are small single-stranded non-coding RNAs that post-transcriptionally regulate gene expression, and play key roles in the regulation of a variety of cellular processes and in disease. New tools to analyze miRNAs will add understanding of the physiological origins and biological functions of this class of molecules.
Majlinda, Kullolli +4 more
openaire +2 more sources
An insight into high-resolution mass-spectrometry data [PDF]
Biostatistics, 2009 Mass spectrometry is a powerful tool with much promise in global proteomic studies. The discipline of statistics offers robust methodologies to extract and interpret high-dimensional mass-spectrometry data and will be a valuable contributor to the field.
Eckel-Passow, Jeanette E. +3 more
openaire +2 more sources
Mass spectrometry imaging with high resolution in mass and space [PDF]
Histochemistry and Cell Biology, 2013 Mass spectrometry (MS) imaging links molecular information and the spatial distribution of analytes within a sample. In contrast to most histochemical techniques, mass spectrometry imaging can differentiate molecular modifications and does not require labeling of targeted compounds. We have recently introduced the first mass spectrometry imaging method
Römpp, Andreas, Spengler, Bernhard
openaire +2 more sources
Rapid high mass resolution mass spectrometry using matrix-assisted ionization [PDF]
Methods, 2016 Matrix-assisted ionization (MAI) is demonstrated to be a robust and sensitive analytical method capable of analyzing proteins such as cholera toxin B-subunit and pertussis toxin mutant from conditions containing relatively high amounts of inorganic salts, buffers, and preservatives without the need for prior sample clean-up or concentration.
Sarah, Trimpin +6 more
openaire +2 more sources
From High- to Super-resolution Mass Spectrometry
CHIMIA, 2014 High-resolution mass spectrometry (MS) is indispensable for the molecular-level analysis of biological and environmental samples with great intra- and inter-molecular complexity. Here, we summarize developments in Fourier transform mass spectrometry (FTMS), the flagship of high-resolution MS techniques, accomplished in our laboratory ...
openaire +5 more sources