Results 31 to 40 of about 248,447 (163)

A system suitability testing platform for untargeted, high-resolution mass spectrometry

Frontiers in Molecular Biosciences, 2022
The broad coverage of untargeted metabolomics poses fundamental challenges for the harmonization of measurements along time, even if they originate from the very same instrument.
Andrei Dmitrenko, Andrei Dmitrenko, Michelle Reid, Nicola Zamboni   +3 more
doaj   +1 more source

The Proteomic Analysis of Platelet Extracellular Vesicles in Diabetic Patients by nanoLC-MALDI-MS/MS and nanoLC-TIMS-MS/MS

Molecules
Platelet extracellular vesicles (PEVs) are emerging as key biomarkers in diabetes mellitus (DM), reflecting altered platelet function and coagulation pathways.
Joanna Kasprzyk-Pochopień, Agnieszka Kamińska, Przemysław Mielczarek, Radosław Porada, Ewa Stępień, Wojciech Piekoszewski   +5 more
doaj   +1 more source

Recent Advances and Future Challenges in Modified Mycotoxin Analysis: Why HRMS Has Become a Key Instrument in Food Contaminant Research

Toxins, 2016
Mycotoxins are secondary metabolites produced by pathogenic fungi in crops worldwide. These compounds can undergo modification in plants, leading to the formation of a large number of possible modified forms, whose toxicological relevance and occurrence ...
Laura Righetti, Giuseppe Paglia, Gianni Galaverna, Chiara Dall’Asta   +3 more
doaj   +1 more source

Indexing Permafrost Soil Organic Matter Degradation Using High-Resolution Mass Spectrometry. [PDF]

PLoS ONE, 2015
Microbial degradation of soil organic matter (SOM) is a key process for terrestrial carbon cycling, although the molecular details of these transformations remain unclear.
Benjamin F Mann, Hongmei Chen, Elizabeth M Herndon, Rosalie K Chu, Nikola Tolic, Evan F Portier, Taniya Roy Chowdhury, Errol W Robinson, Stephen J Callister, Stan D Wullschleger, David E Graham, Liyuan Liang, Baohua Gu   +12 more
doaj   +1 more source

Ultra-Trace Analysis of Cyanotoxins by Liquid Chromatography Coupled to High-Resolution Mass Spectrometry

Toxins, 2020
The increasing frequency of episodes of harmful algal blooms of cyanobacterial origin is a risk to ecosystems and human health. The main human hazard may arise from drinking water supply and recreational water use.
Daria Filatova, Oscar Núñez, Marinella Farré   +2 more
doaj   +1 more source

Assessment of tandem mass spectrometry and high‐resolution mass spectrometry for the analysis of bupivacaine in plasma [PDF]

Biomedical Chromatography, 2015
AbstractTriple quadrupole mass spectrometers coupled with high performance liquid chromatography are workhorses in quantitative bioanalyses. They provide substantial benefits including reproducibility, sensitivity and selectivity for trace analysis.
Gaudette, Fleur, Benito, Javier, Steagall, Paulo, Beaudry, Francis   +3 more
openaire   +2 more sources

High-resolution acoustic ejection mass spectrometry for high-throughput library screening

SLAS Technology
An approach is described for high-throughput quality assessment of drug candidate libraries using high-resolution acoustic ejection mass spectrometry (AEMS).
Nate Hoxie, David R. Calabrese, Zina Itkin, Glenn Gomba, Min Shen, Meghav Verma, John S. Janiszewski, Jonathan H. Shrimp, Kelli M. Wilson, Sam Michael, Matthew D. Hall, Lyle Burton, Tom Covey, Chang Liu   +13 more
doaj   +1 more source

Mass Spectrometric QUAL/QUAN Approaches for Drug Metabolism and Metabolomics

CHIMIA, 2012
A liquid chromatography–high-resolution mass spectrometry platform was used for simultaneous qualitative and quantitative (QUAL/QUAN) acquisition, enabling drug metabolism and metabolomics investi- gations.
David Tonoli, Emmanuel Varesio, Gérard Hopfgartner   +2 more
doaj   +1 more source

Mapping an atlas of tissue-specific Drosophila melanogaster metabolomes by high resolution mass spectrometry. [PDF]

PLoS ONE, 2013
Metabolomics can provide exciting insights into organismal function, but most work on simple models has focussed on the whole organism metabolome, so missing the contributions of individual tissues.
Venkateswara R Chintapalli, Mohammed Al Bratty, Dominika Korzekwa, David G Watson, Julian A T Dow   +4 more
doaj   +1 more source

Non-targeted screening of emerging contaminants in drinking water based on high-resolution mass spectrometry

Shanghai yufang yixue, 2023
ObjectiveTo establish a non-targeted screening method for emerging contaminants in drinking water based on high-resolution mass spectrometry and apply it to actual water samples.MethodsA total of 9 drinking water samples collected from 3 reservoirs in ...
WU Linying, FENG Chao, WANG Guoquan, XUAN Dongliang, JIN Yu’e, PENG Qian, LU Dasheng   +6 more
doaj   +1 more source