Results 21 to 30 of about 311,623 (216)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

First Results from WINERED: Detection of Emission Lines from Neutral Iron and a Combined Set of Trace Species on the Dayside of WASP-189 b

The Astronomical Journal
Ground- and space-based observations have revealed that ultrahot Jupiters (UHJs, T _eq  > 2200 K) typically have inverted thermal profiles, while cooler hot Jupiters have noninverted ones.
Lennart van Sluijs, Emily Rauscher, Eliza M.-R. Kempton, Thomas Kennedy, Isaac Malsky, Noriyuki Matsunaga, Michael Meyer, Andrew McWilliam, John D. Monnier, Shogo Otsubo, Yuki Sarugaku, Tomomi Takeuchi   +11 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

High-precision Near-infrared Abundances of Solar Analogs in the YJ Bands

The Astrophysical Journal Supplement Series
We present a near-infrared abundance analysis of 46 solar analogs with known ages, observed with the WINERED WIDE-mode spectrograph at a resolution of λ /Δ λ  = 28,000.
Noriyuki Matsunaga, Takuji Tsujimoto, Daisuke Taniguchi, Hiroaki Sameshima, Shogo Otsubo, Tomomi Takeuchi, Yuki Sarugaku, Ilaria Petralia, Scarlet Elgueta, Matilde Coello-Guzmán, Kei Fukue, Yuji Ikeda, Hideyo Kawakita, Valentina D’Orazi, Giuseppe Bono   +14 more
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

High-resolution neutron spectroscopy on protein solution samples

EPJ Web of Conferences, 2015
Proteins in solution move subject to a complex superposition of global translational and rotational diffusion as well as internal relaxations covering a wide range of time scales. With the advent of new high-flux neutron spectrometers in combination with
Grimaldo Marco, Roosen-Runge Felix, Jalarvo Niina, Zamponi Michaela, Zanini Fabio, Hennig Marcus, Zhang Fajun, Schreiber Frank, Seydel Tilo   +8 more
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Fast acquisition of high resolution liquid NMR spectroscopy

Magnetic Resonance Letters
Nuclear magnetic resonance (NMR) spectroscopy is a powerful tool for analyzing molecular structure and composition. However, traditional NMR experiments suffer from long acquisition times, especially in multidimensional NMR spectroscopy. This problem, to
Wen Zhu, Mengjie Qiu, Yao Luo, Xiaoqi Shi, Zhong Chen, Yanqin Lin   +5 more
doaj   +1 more source

Analysis and Authentication of Avocado Oil Using High Resolution NMR Spectroscopy

Molecules, 2021
Avocado oil is a food product of high commercial and nutritional value. As a result, it can be a subject of adulteration similar to other high-value edible oils, such as olive oil.
Fenfen Tang, Hilary S. Green, Selina C. Wang, Emmanuel Hatzakis   +3 more
doaj   +1 more source