Results 71 to 80 of about 16,837,468 (303)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

The impact of interpolation in high-resolution spectroscopy

Astronomy & Astrophysics
Aims. We explore the impact that spectral interpolation introduces in radial velocity (RV) time-series that are extracted using templatebased methods, in particular systematic biases induced in this process. Methods.
Silva A. M., Doshi D., Al Moulla K., Cristo E. A. S., Artigau É., Viana P. T. P., Santos N. C., Martins J. H. C., Marques C. M. J., Sousa S. G., San Nicolas Martinez C., Campante T. L., Cabral A., Cristiani S.   +13 more
doaj   +1 more source

PDS 70b Shows Stellar-like Carbon-to-oxygen Ratio

The Astrophysical Journal Letters
The ~5 Myr PDS 70 is the only known system with protoplanets residing in the cavity of the circumstellar disk from which they formed, ideal for studying exoplanet formation and evolution within its natal environment.
Chih-Chun Hsu, Jason J. Wang, Geoffrey A. Blake, Jerry W. Xuan, Yapeng Zhang, Jean-Baptiste Ruffio, Katelyn Horstman, Julianne Cronin, Ben Sappey, Yinzi Xin, Luke Finnerty, Daniel Echeverri, Dimitri Mawet, Nemanja Jovanovic, Clarissa R. Do Ó, Ashley Baker, Randall Bartos, Benjamin Calvin, Sylvain Cetre, Jacques-Robert Delorme, Gregory W. Doppmann, Michael P. Fitzgerald, Joshua Liberman, Ronald A. López, Evan Morris, Jacklyn Pezzato-Rovner, Tobias Schofield, Andrew Skemer, J. Kent Wallace, Ji Wang   +29 more
doaj   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Updated System of S i Levels Using Fourier Transform Infrared Spectroscopy in the Range from 800 to 11,000 cm−1

The Astrophysical Journal Supplement Series
In this study we report on high-precision laboratory measurements of transition wavenumbers for 172 atomic sulfur lines in the infrared region 800–11,000 cm ^−1 using Fourier transform spectroscopy techniques. Our analysis includes 96 lines that have not
S. Civiš, A. Kramida, E. M. Zanozina, J. Kubišta, P. Kubelík, M. Ferus, V. E. Chernov   +6 more
doaj   +1 more source

High-Resolution X-Ray Spectroscopy of Galactic Supernova Remnants

Acta Polytechnica CTU Proceedings, 2014
High-resolution X-ray spectroscopy of Galactic supernova remnants (SNRs), based on grating spectrometers onboard XMM-Newton and Chandra, has been revealing a variety of new astrophysical phenomena.
Satoru Katsuda, Hiroshi Tsunemi
doaj   +1 more source