Results 51 to 60 of about 311,623 (216)

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

PDS 70b Shows Stellar-like Carbon-to-oxygen Ratio

The Astrophysical Journal Letters
The ~5 Myr PDS 70 is the only known system with protoplanets residing in the cavity of the circumstellar disk from which they formed, ideal for studying exoplanet formation and evolution within its natal environment.
Chih-Chun Hsu, Jason J. Wang, Geoffrey A. Blake, Jerry W. Xuan, Yapeng Zhang, Jean-Baptiste Ruffio, Katelyn Horstman, Julianne Cronin, Ben Sappey, Yinzi Xin, Luke Finnerty, Daniel Echeverri, Dimitri Mawet, Nemanja Jovanovic, Clarissa R. Do Ó, Ashley Baker, Randall Bartos, Benjamin Calvin, Sylvain Cetre, Jacques-Robert Delorme, Gregory W. Doppmann, Michael P. Fitzgerald, Joshua Liberman, Ronald A. López, Evan Morris, Jacklyn Pezzato-Rovner, Tobias Schofield, Andrew Skemer, J. Kent Wallace, Ji Wang   +29 more
doaj   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

Updated System of S i Levels Using Fourier Transform Infrared Spectroscopy in the Range from 800 to 11,000 cm−1

The Astrophysical Journal Supplement Series
In this study we report on high-precision laboratory measurements of transition wavenumbers for 172 atomic sulfur lines in the infrared region 800–11,000 cm ^−1 using Fourier transform spectroscopy techniques. Our analysis includes 96 lines that have not
S. Civiš, A. Kramida, E. M. Zanozina, J. Kubišta, P. Kubelík, M. Ferus, V. E. Chernov   +6 more
doaj   +1 more source

High-Resolution X-Ray Spectroscopy of Galactic Supernova Remnants

Acta Polytechnica CTU Proceedings, 2014
High-resolution X-ray spectroscopy of Galactic supernova remnants (SNRs), based on grating spectrometers onboard XMM-Newton and Chandra, has been revealing a variety of new astrophysical phenomena.
Satoru Katsuda, Hiroshi Tsunemi
doaj   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Basic characterization of uranium by high-resolution gamma spectroscopy

Nuclear Engineering and Technology, 2018
A basic characterization of uranium samples was performed using gamma- and X-ray spectroscopy. The studied uranium samples were eight types of certified reference materials with 235U enrichments in the range of 1–97%, and the measurements were performed ...
Hee-Dong Choi, Junhyuck Kim
doaj   +1 more source

Optimization of seminal extracellular vesicle isolation protocols for cancer biomarker analysis using proteomic profiling

Molecular Oncology, EarlyView.
This paper shows that size‐exclusion chromatography and sequential centrifugation applied to seminal plasma enrich for different populations of extracellular vesicles. This may significantly affect the detection and analysis of extracellular vesicle‐associated cancer biomarkers.
Elen Telumyan, Beatriz Martín‐Gracia, Eva Bassols‐Citores, Krizia Sagini, Maria K. Andersen, Tuula A. Nyman, May‐Britt Tessem, Morten B. Rye, Alicia Llorente   +8 more
wiley   +1 more source

High-Resolution Photoelectron Spectroscopy and ab initio Quantum Chemistry

CHIMIA, 2004
The resolution that can be achieved by photoelectron spectroscopy has been continually improved over the past 50 years and is now sufficiently high for the rovibronic energy level structure of polyatomic molecular cations to be measured accurately ...
Stefan Willitsch, Andrea Wüest, Frédéric Merkt   +2 more
doaj   +1 more source