SMAD4 is identified as a guardian of 3D genome architecture in lung squamous cell carcinoma. Loss of SMAD4 unleashes EP300 at chromatin loop anchors, strengthening enhancer–promoter looping and H3K27ac at the SOX2 locus to drive aberrant SOX2 activation and tumor cell proliferation.
Qian Tang +33 more
wiley +1 more source
Knowledge and attitudes of cervical cancer screening among female high school teachers in Hail city: A cross-sectional study. [PDF]
Alshammiri SM.
europepmc +1 more source
The study proposes a fitting curve as a reference to quantify the optimal K+ ratio in K+/Zn2+ mixed electrolyte, thus achieving stable and high‐capacity aqueous zinc ion batteries at each current density. ABSTRACT Incorporating K+ into Zn‐based electrolytes can enhance the performance of aqueous zinc ion batteries, while the lack of a clear rule for ...
Yewei Li +7 more
wiley +1 more source
Magnitude and influencing factors of work-related low back pain among high school teachers in West Arsi zone, Southwest Ethiopia: evidenced from multicentred cross-sectional study. [PDF]
Gemedo S +3 more
europepmc +1 more source
PDIA6–SCD1 Axis Rewires Lipid Metabolism to Drive Gastric Cancer Progression
Protein disulfide isomerase A6 (PDIA6) is identified as an oncogenic driver in gastric cancer. PDIA6 directly binds and stabilizes SCD1 by limiting its ubiquitin–proteasome‐mediated degradation, thereby sustaining monounsaturated fatty acid (MUFA)‐enriched lipid homeostasis and lipid metabolic reprogramming.
Zhen Tian +13 more
wiley +1 more source
Psychological and Physical Changes Caused by COVID-19 Pandemic in Elementary and Junior High School Teachers: A Cross-Sectional Study. [PDF]
Wakui N +10 more
europepmc +1 more source
Antimicrobial resistance caused by Gram‐negative bacteria remains difficult to overcome due to the protective outer membrane. To address this challenge, a multi‐condition constrained generative AI framework, GenMTAMP is proposed for de novo membrane‐targeting antimicrobial peptide design by integrating physicochemical and spatial structure descriptors.
Jingxiao Yu +5 more
wiley +1 more source
A Cluster Randomized Pilot Trial of the Equity-Explicit Establish-Maintain-Restore Program among High School Teachers and Students. [PDF]
Duong MT +8 more
europepmc +1 more source
Sliding Ferroelectricity Driven Spin‐Layertronics in Altermagnetic Multilayers
Integrating sliding ferroelectricity with altermagnetism enables nonvolatile electrical control of spin and layer degrees of freedom. In bilayer CuF2, interlayer translation reverses layer‐locked spin‐split bands, establishing a multifunctional “spin‐layertronic” platform.
Rui Peng +5 more
wiley +1 more source

