Results 131 to 140 of about 1,651,428 (315)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
CALIBRATING THE INTERCITY HIGH SPEED RAIL (HSR) CHOICE MODEL FOR THE RICHMOND-WASHINGTON, D.C. CORRIDOR [PDF]
This study aims to quantitatively investigate how the introduction of high-speed rail (HSR) influences traveler’s choice behavior. The study focuses on recalibrating the Florida-based HSR choice model to fit the intercity travel northward from Richmond ...
Xueming CHEN
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Feature Extraction for Carbide Classification of High Speed Steel [PDF]
, 1995 : A new feature extraction method for the purpose of carbide classification of high speed steels is introduced. By means of thresholding, filtering, closing and region labeling we generate a characteristic structure of the carbides.
Axel Pinz +3 more
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Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Tri-state study of high speed rail service [PDF]
This report, the Final Report for the Tri-State Study of High Speed Rail Service, describes the work carried out by TMS/Benesch in analyzing the potential for high speed rail in the Tri-State Corridor.
TMS/Benesch Tri-State High Speed Rail Consultants
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High speed short range optical wireless ground-to-train communications [PDF]
, 2010 There is a huge demand for seamless high-speed communications in fast moving trains. People want broadband services while on board as in their home or in the workplace.
Ghassemlooy, Zabih +3 more
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Hot Tensile Behavior of 05Cr17Ni4Cu4Nb Stainless Steel: Damage Model and Fracture Characteristics
MetalsThis study investigates the hot tensile behavior and fracture characteristics of 05Cr17Ni4Cu4Nb stainless steel through isothermal tensile tests conducted under various deformation parameters.
Jing Yuan +3 more
doaj +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source