Results 111 to 120 of about 1,651,428 (315)

Geometrically Nonlinear Static Analysis of High-Aspect-Ratio Truss-Braced Wing

Engineering Proceedings
Truss-braced wings (TBWs) feature higher aspect ratios with a lighter weight and lower bending moment than conventional wings. These wings show significant potential for performance improvements in terms of fuel efficiency.
Yanxin Huang, Jinchi Chen, Qingyuan Ma
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Inappropriate high speed: who does it and why? [PDF]

, 2006
Inappropriate high speeds are associated with increases in crash probability and severity, and we need to understand why they happen if we are to design workable interventions.
Hannigan, B, Bates, H, Fuller, R, Stradling, Stephen G, Gormley, M, Broughton, Paul, O'Dolan, Catriona, Kinnear, Neale A D   +7 more
core  

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Calculation and uncertainty analysis method for airfoil drag coefficient considering compressibility

AIP Advances
In order to meet the need of evaluating the effectiveness of airfoil drag reduction design, the calculation and uncertainty analysis method for airfoil drag coefficient considering compressibility is studied.
Yufeng Du, Qiuting Guo, Lulu Wang, Jilong Zhu, Neng Xiong   +4 more
doaj   +1 more source

A New Mechanism of Canopy Effect in Unsaturated Freezing Soils

E3S Web of Conferences, 2016
Canopy effect refers to the phenomenon where moisture accumulates underneath an impervious cover. Field observation reveals that canopy effect can take place in relatively dry soils where the groundwater table is deep and can lead to full saturation of ...
Teng Jidong, Zhang Sheng, He Zuoyue, Sheng Daichao   +3 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Data-driven capacity planning of highway multi-energy systems under photovoltaic uncertainty using CVAE-enhanced distributionally robust optimization

Frontiers in Energy Research
Capacity planning in highway multi-energy systems faces significant challenges due to the high uncertainty of renewable energy generation and the limited availability of historical data during the planning stage.
Guomu Xie, Guomu Xie, Xuefei Liu, Hongjie Li, Hongjie Li, Yuanyuan Song, Jikai Fu, Jikai Fu, Jibin Zhang, Jibin Zhang, Shishan Dong, Shishan Dong   +11 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source