Results 91 to 100 of about 16,083,913 (302)
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
ABOUT INFLUENCE OF SPEED WORKING BODIES OF DIGGING MACHINES ON THE RESISTANCE FORCE OF SOIL CUTTING
Вестник СибАДИ, 2017 The processes occurring during high-speed cutting of soil is are considered. The dependence of the resistance force of soil cutting from speed of interaction, taking into account the compressibility of soil and the occurrence of wave drag forces is ...
D. S. Semkin
doaj +1 more source
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
Research Progress of Noise in High-Speed Cutting Machining. [PDF]
Sensors (Basel), 2022 Wei W, Shang Y, Peng Y, Cong R.
europepmc +1 more source
Molecular Oncology, EarlyView.This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic +10 more
wiley +1 more source
Influence of Different Material Models on the Result of Numerical High Speed Cutting Simulations [PDF]
, 2004 Extreme conditions for the workpiece and the tool can occur in high speed cutting processes. Temperatures above 1000 °C at very high strains over 3 and strain rates near 105 1/s are not unusual.
Meyer, L. W., Halle, T.
core +1 more source
Influence of Cutting Depth on Rock Breaking Mechanism of PDC Cutter at Ultra-High Speed
Shiyou jixie, 2022 Ultra-high speed diamond drilling technology,which is characterized by high drilling efficiency with substantially lower low energy and load,is one of the effective means to improve ROP in deep and hard rock drilling.In order to understand the influence ...
Li Qizhou +5 more
doaj
Archives of Metallurgy and Materials, 2017 This paper presents the influence of cutting parameters (Depth of cut, feed rate, spindle speed and cutting fluid flow rate) on the surface roughness and flank wear of physical vapor deposition (PVD) Cathodic arc evaporation coated TiAlN tungsten carbide
Moganapriya C. +4 more
doaj +1 more source
A Novel Biopsy Capsule Robot Based on High-Speed Cutting Tissue. [PDF]
Cyborg Bionic Syst, 2022 Song Z, Zhang W, Zhang W, Paolo D.
europepmc +1 more source