Results 71 to 80 of about 89,586 (267)

Influence of Cutting Fluid Flow Rate and Cutting Parameters on the Surface Roughness and Flank Wear of TiAlN Coated Tool In Turning AISI 1015 Steel Using Taguchi Method

Archives of Metallurgy and Materials, 2017
This paper presents the influence of cutting parameters (Depth of cut, feed rate, spindle speed and cutting fluid flow rate) on the surface roughness and flank wear of physical vapor deposition (PVD) Cathodic arc evaporation coated TiAlN tungsten carbide
Moganapriya C., Rajasekar R., Ponappa K., Venkatesh R., Karthick R.   +4 more
doaj   +1 more source

Positron Annihilation Spectroscopy Study of Metallic Materials after High-Speed Cutting. [PDF]

Materials (Basel), 2022
Li J, Laptev R, Bordulev I, Siemek K, Horodek P, Shen H, Lomygin A, Cui J.   +7 more
europepmc   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Determination of Optimum Machining Parameters in Machining Rene 41 Superalloy Depending on Cutting Speed [PDF]

E3S Web of Conferences
Rene 41 superalloy developed to withstand severe mechanical stresses and high temperature operation, and are widely used in aircraft and space vehicles, especially nickel-based ones, due to their high corrosion resistance.
Altin Abdullah, Altin Muhammed Cihat, Altin Hilal, Altin Tuğba   +3 more
doaj   +1 more source

Comparison of Surgical Smoke Generated During Electrosurgery with Aerosolized Particulates from Ultrasonic and High-Speed Cutting. [PDF]

Ann Biomed Eng, 2021
Casey VJ, Martin C, Curtin P, Buckley K, McNamara LM.   +4 more
europepmc   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Research on High Speed Cutting Parameter Optimization and Fault Diagnosis Technology

Advances in Mechanical Engineering, 2014
High speed cutting process is a very complicated process; cutting parameters have a significant effect on cutting process and play a key role in the process of product manufacturing. The overall scheme of high speed cutting parameter optimization and its
Honggen Zhou, Xuwen Jing, Lei Wang, Kaiyun Dai, Jia Yongpeng   +4 more
doaj   +1 more source

Contributions of High-Speed Cutting and High Rake Angle to the Cutting Performance of Natural Rubber

International Journal of Automation Technology, 2014
This study investigates the contributions of high-speed cutting and a high rake angle to the improvement of the cutting performance of natural rubber. Orthogonal cutting experiments were conducted at cutting speeds ranging from 1.0 m/s to 141.1 m/s. The rake angles examined were 0°, 20° and 50°. The following results were obtained from the experiments.
Naoki Takahashi, Jun Shinozuka
openaire   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source