Results 71 to 80 of about 16,083,913 (302)

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Simulation of Flow Stress Characteristic During Two-stage Hot Deformation Process in AZ31B Magnesium Alloy

Journal of Aeronautical Materials, 2017
A 2-D CA model has been developed to simulate two-stage hot deformation processing of magnesium (Mg) alloy. Based on the fact that Mg has an HCP crystal structure with six-fold symmetry, the model employs hexagonal CA lattice.
DENG Xiaohu, HU Xiaodong, ZHAO Hongyang, JU Dongying   +3 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Critical cutting speed for onset of serrated chip flow in high speed machining

, 2014
The transition of continuously smooth chip flow to periodically serrated chip flow as the cutting speed increasing is one of the most fundamental and challenging problems in high speed machining. Here, an explicit expression of the critical cutting speed
Ye GG, Xue SF, Dai, LH (reprint author), Chinese Acad Sci, Inst Mech, State Key Lab Nonlinear Mech, Beijing 100190, Peoples R China., Dai LH(戴兰宏), Chen Y(陈艳)   +4 more
core   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Toward a better understanding of tool wear effect through a comparison between experiments and SPH numerical modelling of machining hard materials [PDF]

, 2009
The aim of this study is to improve the general understanding of tungsten carbide (WC–Co) tool wear under dry machining of the hard-to-cut titanium alloy Ti6Al4V. The chosen approach includes experimental and numerical tests.
Salaün, Michel, Chieragatti, Rémy, M. Salaün, GIROT, Franck, Espinosa, Christine, Girot, F., COUPARD, Dominique, Nouari, Mohammed, J. Limido, D. Coupard, R. Chieragatti, Calamaz, Madalina, F. Girot, C. Espinosa, M. Calamaz, M. Nouari, Coupard, D., Limido, Jérôme   +17 more
core   +1 more source

An investigation on micro cutting mechanics: Modelling, simulations and experimental case studies [PDF]

, 2014
This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University London.Micro cutting is becoming increasingly important since miniature and micro components/products have become more and more demanded in precision ...
Sawangsri, Worapong
core   +6 more sources

Influence of deposition pressure on structure and properties of AlCrSiN/Mo self-lubricating coating

Cailiao gongcheng
To solve the problem that the cutting temperature rises sharply due to the high friction coefficient of AlCrSiN coated tools during dry cutting， which seriously shortens the service life of the tool， the tribological properties of the coating are ...
WANG Chongyang, LIU Yanmei, LIAN Weifeng, ZHANG Yinhang, HE Meng, XUE Rui, LYU Yuanjiang, LIU Datong, XU Yuanjian, WANG Tiegang   +9 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source