From mice to humans—divergent strategies for intestinal homeostasis and regeneration
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
On the Cutting Test of the High Speed Planer.
従耒の調帯掛け普通平削盤とワードレオナルド方式高速平削盤との比較切削試験を試み、理論的立場といふよりは寧ろ現場的立場に重点を置き、工場に於て実際に使用し得るに便利な簡易なる切削力測定器を作り、それに依て両者の特異性を明らかにせんとしたものである。この目的のために普通平削盤にはシンシナチ製 20ft ベルト掛け平削盤、高速平削盤にはニイガタ 5D型標準高速平削盤を使用し、同一なる材質、形状及び大きさを有する被切削材を、各機に適應した実用的の切削条件の下に於て比較切削試験を行つたものである。
SANGU, TAIDI, Hosr, Koiti
openaire +2 more sources
Experimental study of the brittle–ductile transition in hot cutting of SG iron specimens [PDF]
http://www.sciencedirect.com/science/article/pii/S0924013612002579The present paper investigates the brittle-ductile transition (BDT) of the primary shear zone during cutting of spheroidal graphite (SG) iron in the austenitization temperature range ...
EL MANSORI, Mohamed +2 more
core +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Research Status of Green Efficient Corrosion Inhibitors [PDF]
Corrosion inhibitors are widely used because they have the characteristics of trace and high efficiency, can prevent metal corrosion,while maintaining the physical and mechanical properties of the metal unchanged, and easy to use.Traditional metal ...
LI Jie, CAO Fengting, WANG Tiegang, LI Tao, CHEN Yong, CAO Jinxin, LIU Yanmei, FAN Qixiang
doaj +1 more source
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Modelling High Speed Machining with the SPH Method [PDF]
The purpose of this work is to evaluate the use of the Smoothed Particle Hydrodynamics (SPH) method within the framework of high speed cutting modelling. First, a 2D SPH based model is carried out using the LS-DYNA® software.
Salaün, Michel +5 more
core
Numerical and analytical modeling of orthogonal cutting : The link between local variables and global contact characteristics [PDF]
The response of the tool–chip interface is characterized in the orthogonal cutting process by numerical and analytical means and compared to experimental results. We study the link between local parameters (chip temperature, sliding friction coefficient,
Miguélez Garrido, María Henar +7 more
core +1 more source
Effects of Deposition Pressure on the Microstructure,Mechanical Behavior and High-Temperature Oxidation Resistance of AlCrTiSiN Coatings [PDF]
Deposition pressure is an important process parameter for coating preparation. To study its influence on the microstructure, mechanical properties and high-temperature oxidation resistance of AlCrTiSiN nanocomposite coatings, two types of AlCrTiSiN ...
GUAN Mengxue, FAN Qixiang, GUO Minglu, ZHANG Shuo, HAO Xuehui, WU Zhenghuan, CAO Fengting, WANG Tiegang
doaj +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source

