Results 91 to 100 of about 380,525 (307)

The effect of using patient-specific guides for total knee replacement without hardware removal in complex post-traumatic arthritis: an in-vitro study

BioMedical Engineering OnLine
Background Post-traumatic knee replacement (PTKR) is frequently complicated by the presence of retained metallic hardware around the joint, which limits the use of intramedullary alignment guides.
Chi-Pin Hsu, Chun-Chieh Chen, Yi-Sheng Chan, Chen-Te Wu, Jeng-Ywan Jeng, Alvin Chao-Yu Chen   +5 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Deep-tissue focal fluorescence imaging with digitally time-reversed ultrasound-encoded light. [PDF]

, 2012
Fluorescence imaging is one of the most important research tools in biomedical sciences. However, scattering of light severely impedes imaging of thick biological samples beyond the ballistic regime.
Wang, Ying Min, DiMarzio, Charles A., Judkewitz, Benjamin, Yang, Changhuei, Dimarzio, Charles A   +4 more
core   +1 more source

When superhydrophobicity can be a drag: ventilated cavitation and splashing effects in hydrofoil and speed-boat models tests

, 2021
Superhydrophobic surfaces are expected to reduce the hydrodynamic drag on marine vessels due to the lubrication effects of the naturally sustained thin air-layer plastron.
Vakarelski, Ivan Uriev, Jetly, Aditya, Kamoliddinov, Farrukh, Thoroddsen, Sigurdur T   +3 more
core   +1 more source

Imaging with an ultra-high-speed video camera operating at 20 Mfps for 300 kpixels

Mechanical Engineering Journal, 2016
An image sensor with 300 kpixels operating at 20 Mfps is developed. Pixels on odd-number and even-number columns can be independently operated. The highest frame rate is 40 Mfps when a time shift of a half of the shortest frame interval is introduced to ...
Hoang Dung NGUYEN, Tomoo OKINAKA, Yasuhide TAKANO, Kohsei TAKEHARA, Vu Truong Son DAO, Takeharu Goji ETOH   +5 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

High-speed imaging of high pressures produced by cavitation bubbles

Cavitation bubbles, when correctly tuned, may provide interesting mechanical and chemical effects to their surroundings owing to their violent collapse.
Supponen, O., Farhat, M., Obreschkow, D.
core   +1 more source

Probing the nanoscale with high-speed interferometry of an impacting drop

, 2017
The simple phenomenon of a water drop falling onto a glass plate may seem like a trivial fluid mechanics problem. However, detailed imaging has shown that this process is highly complex and a small air-bubble is always entrapped under the drop when it ...
Vakarelski, Ivan Uriev, Langley, Kenneth, Thoroddsen, Sigurdur T, Li, Erqiang   +3 more
core   +1 more source

FluorATOM: high-throughput imaging flow cytometry for synchronized biophysical and biomolecular phenotyping

, 2020
Multiplexed asymmetric-detection time-stretch optical microscopy (multi-ATOM) has recently been developed to enable high-throughput quantitative phase imaging flow cytometry, from which single-cell biophysical properties can be measured at large scale ...
Kwong, A, Wong, KKY, Lee, KCM, Wang, M, Shin, VY, Tsia, KKM, Cheuk, WYI, So, HKH   +7 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source