Results 111 to 120 of about 164,121 (308)
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
A New Fully Soft‐Switching High Step‐Up Interleaved Converter for Optimal Efficiency
IET Power ElectronicsA novel fully soft‐switching interleaved high step‐up converter is introduced in this paper. The suggested converter achieves high voltage gain using coupled inductors (CI) and a voltage multiplier cell (VMC).
Arsalan Erfani +2 more
doaj +1 more source
Isolated High Step-Up DC–DC Converter With Low Voltage Stress
IEEE Transactions on Power Electronics, 2014 Fuel cell stacks and photovoltaic panels generate rather low dc voltages and these voltages need to be boosted before converted to ac voltage. Therefore, high step-up ratio dc-dc converters are preferred in renewable energy systems. A new Z-source-based topology that can boost the input voltage to desired levels with low duty ratios is proposed in this
Evran, Fatih, Aydemir, Mehmet Timur
openaire +3 more sources
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Hybrid Switched Capacitor Three Winding Coupled Inductor High Step-Up DC-DC Converter
IEEE AccessSwitched capacitor cells have been studied in recent years. These approaches allow different new topologies to be generated. One such technique is the hybrid converter, where a coupled inductor and switched capacitor can be combined. Thus, in this paper,
Antonio Manuel Santos Spencer Andrade +2 more
doaj +1 more source
Low Input Ripple High Step-Up Extendable Hybrid DC-DC Converter
IEEE Access, 2019 The widely utilization of renewable energy with low output voltage makes the high voltage ratio boosting converter more popular. This article introduces a non-isolated low input ripple high step-up extendable hybrid DC-DC converter.
Guoqing Lin, Zhou Zhang
doaj +1 more source
IET Power Electronics, 2011 Non-isolated high step-up DC-DC converters are required widely in the industrial applications. Many of these conventional DC-DC converters have the disadvantages of operating at high duty-cycle, high switch voltage stress and high diode peak current.
Y. Zhao, W. Li, Y. Deng, X. He
openaire +1 more source
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
Apparatus and method for characterizing the transmission efficiency of a mass spectrometer [PDF]
, 1990 An electron/ion coincidence technique is employed to characterize the absolute mass dependent transmission efficiency of mass spectrometers. The technique is not dependent upon the partial pressure of the sample beam or the ionization cross sections of ...
Srivasytava, Santash
core +1 more source