Results 91 to 100 of about 22,401,602 (289)

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

High Step-Up Converter Based on Non-Series Energy Transfer Structure for Renewable Power Applications. [PDF]

Micromachines (Basel), 2021
Diaz-Saldierna LH, Leyva-Ramos J.
europepmc   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

A New Fully Soft‐Switching High Step‐Up Interleaved Converter for Optimal Efficiency

IET Power Electronics
A novel fully soft‐switching interleaved high step‐up converter is introduced in this paper. The suggested converter achieves high voltage gain using coupled inductors (CI) and a voltage multiplier cell (VMC).
Arsalan Erfani, Majid Delshad, Ehsan Adib   +2 more
doaj   +1 more source

Dual-Coupled-Inductor-Based High-Step-Up Boost Converter with Active-Clamping and Zero-Voltage Switching

Energies
Many applications, such as photovoltaic systems, uninterruptible power supplies, and automobile headlamps, need a high step-up DC–DC converter without isolation.
Sheng-Hua Chen, Chuan-Ting Chen, Yi-Feng Lin   +2 more
doaj   +1 more source

Low Input Ripple High Step-Up Extendable Hybrid DC-DC Converter

IEEE Access, 2019
The widely utilization of renewable energy with low output voltage makes the high voltage ratio boosting converter more popular. This article introduces a non-isolated low input ripple high step-up extendable hybrid DC-DC converter.
Guoqing Lin, Zhou Zhang
doaj   +1 more source

Non-isolated high step-up converter based on boost integrated half-bridge converter

, 2009
A classical boost converter has a limited voltage step-up ratio because of its parasitic resistances, which does not make it suitable for high step-up applications.
Moon, Gun-Woo, Youn, Myung-Joong, Park, Ki-Bum, Kim, Chong-Eun, Myung-Joong Youn, Ki-Bum Park, Gun-Woo Moon, Chong-Eun Kim   +7 more
core   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Hybrid Switched Capacitor Three Winding Coupled Inductor High Step-Up DC-DC Converter

IEEE Access
Switched capacitor cells have been studied in recent years. These approaches allow different new topologies to be generated. One such technique is the hybrid converter, where a coupled inductor and switched capacitor can be combined. Thus, in this paper,
Antonio Manuel Santos Spencer Andrade, Pablo Henrique Costa da Silva Bernardo Loureiro, Ademir Toebe   +2 more
doaj   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source