Results 71 to 80 of about 19,718 (219)

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

New single-switch buck–boost converter with continuous input/output currents and a wide conversion range

Heliyon
The main aim of this paper is to introduce a new high step-up/down buck-boost converter with a minimum number of switches which provides the benefit of having the continuity of the input/output current.
Mohammad Lotfi-nejad, Hossein Hajisadeghian, Amir Abbas Aghajani, Ali A. Motie Birjandi, Ehsan Adib   +4 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

A high step‐up high step‐down coupled inductor based bidirectional DC–DC converter with low voltage stress on switches

IET Power Electronics
This paper proposes, a novel soft‐switching bidirectional direct current to direct current (DC–DC) converter based on switched‐capacitor and coupled‐inductor.
Pouya Abolhassani, Mohammad Maalandish, Ali Nadermohammadi, Mohammad Bagher Bannae Sharifian, Mohammad Reza Feyzi, Seyed Hossein Hosseini   +5 more
doaj   +1 more source

Ultra-High Gain Quadratic DC-DC Topology Using Two-Winding Coupled Inductors With Voltage Multiplier Cells

IEEE Open Journal of Power Electronics
High-gain DC-DC converters have become very important devices in the operation of renewable energy methods such as wind and solar power to provide the required voltage and current levels.
Sohrab Abbasian, Mohammad Farsijani, Homayon Soltani Gohari, Tomi Roinila   +3 more
doaj   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

High Step-Up ZVT Converter Based on Active Switched Coupled Inductors

IEEE Access
To meet the requirements of high voltage boosting and high efficiency, a novel high step-up zero voltage transition (ZVT) DC/DC converter based on active switched-inductor (ASL) is proposed.
Yu Tang, Haisheng Tong, Raheel Afzal, Yingjun Guo   +3 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Research on Coupled Inductor Interleaved High Step-Up DC-DC Converter

Energies
This paper presents a high-voltage step-up DC-DC converter with an active flexible loop based on the Boost topology. By combining interleaved technology, magnetic integration technology, and voltage doubling capacitor technology, the voltage step-up of ...
Chao Wang, Yu Gu, Hanyang Li
doaj   +1 more source