Results 71 to 80 of about 7,826,326 (312)

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Effect of Low Angle Grain Boundaries on Mechanical Properties of DD5 Single Crystal Ni-base Superalloy

Journal of Aeronautical Materials, 2017
The effects of low angle grain boundaries on the mechanical properties of second generation single crystal superalloy DD5 were investigated and the test specimens were prepared by using seeds.
QIN Jianchao, CUI Renjie, HUANG Zhaohui, ZHAO Jingqian, ZHANG Yipeng, ZONG Cui, CHEN Shengping   +6 more
doaj   +1 more source

Tungsten Behavior at High Temperature and High Stress [PDF]

, 2010
Re­cent­ly re­port­ed re­sults on the tung­sten life­time/fa­tigue tests under con­di­tions ex­pect­ed in the Neu­tri­no Fac­to­ry tar­get have strength­ened the case of solid tar­get op­tion for a Neu­tri­no Fac­to­ry.
Back, J.J., Bennett, J.R.J., Booth, C.N., Edgecock, R., Gray, S.A., McFarland, A.J., Škoro, G.P.   +6 more
core  

Spectral function at high temperature [PDF]

, 2001
For a weakly coupled quantum field at high temperature the classical approximation offers a possibility to gain insight into nonperturbative real-time dynamics.
Aarts, Aarts, Bödeker, Gert Aarts
core   +3 more sources

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Low-temperature corrosion in large-scale biomass boilers

npj Materials Degradation
The shift toward biomass fuels for heat and power generation has introduced a range of new challenges for power plant technology, in particular large-scale boilers.
Farzad Jafarihonar, Emil Vainio, Leena Hupa, Mikko Hupa   +3 more
doaj   +1 more source

Temperature dependence of Vortex Charges in High Temperature Superconductors [PDF]

, 2003
Using a model Hamiltonian with d-wave superconductivity and competing antiferromagnetic (AF) interactions, the temperature (T) dependence of the vortex charge in high T_c superconductors is investigated by numerically solving the Bogoliubov-de Gennes ...
A. Ghosal, B. Lake, C. S. Ting, Ch. Renner, D.I. Khomskii, D.P. Arovas, E. Demler, G. Blatter, H.D. Chen, J. Kolacek, Jian-Xin Zhu, K. Kumagai, K.M. Lang, M. Franz, M. Ichioka, M. Takigawa, N. Hayashi, N. Ogata, P. Lipavsky, R.I. Miller, S.H. Pan, S.H. Pan, T. Nagaoka, V.F. Mitrovic, Y. Wang, Yan Chen, Yan Chen, Yan Chen, Yan Chen, Z. D. Wang, Z.D. Wang   +30 more
core   +2 more sources

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source