Results 91 to 100 of about 27,398,055 (316)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

TRM vs FRP jacketing in shear strengthening of concrete members subjected to high temperatures

, 2016
This paper presents the first study on the performance of TRM and FRP jacketing in shear strengthening of reinforced concrete (RC) members subjected to ambient and high temperatures, including both medium-scale rectangular beams and full-scale T-beams ...
Z. Tetta, D. Bournas
semanticscholar   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

HIGH TEMPERATURE SYMMETRY NONRESTORATION [PDF]

COSMO-99, 2000
This is a short review on the subject of symmetry nonrestoration at high temperature. Special emphasis is put on experimental discoveries and different theoretical mechanisms. At the end, possible cosmological applications are briefly mentioned.
openaire   +2 more sources

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

The Influence of External Radiation on the Emission Properties of H- and He-like Argon Ions in High Temperature Plasma

Atoms
In the present work, the influence of external X-ray radiation on the kinetics of multicharged ions in high-temperature plasma is investigated. A generalized diagnostic approach is proposed for the electron density and temperature measurements of photo ...
Roman K. Kulikov, Igor Yu. Skobelev, Evgeny D. Filippov   +2 more
doaj   +1 more source

Coulomb stable structures of charged dust particles in a dynamical trap at atmospheric pressure in air

New Journal of Physics, 2013
A mathematical simulation of a dust particle's behavior in the electrodynamic linear quadrupole trap with closing end electrodes allowed us to reveal several features of the phenomena.
L M Vasilyak, V I Vladimirov, L V Deputatova, D S Lapitsky, V I Molotkov, V Ya Pecherkin, V S Filinov, V E Fortov   +7 more
doaj   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

High-temperature Josephson diode

Nature Materials
Symmetry plays a critical role in determining various properties of a material. Semiconducting p-n junction diode exemplifies the engineered skew electronic response and is at the heart of contemporary electronic circuits. The non-reciprocal charge transport in a diode arises from doping-induced breaking of inversion symmetry. Breaking of time-reversal,
Sanat Ghosh, Vilas Patil, Amit Basu, null Kuldeep, Achintya Dutta, Digambar A. Jangade, Ruta Kulkarni, A. Thamizhavel, Jacob F. Steiner, Felix von Oppen, Mandar M. Deshmukh   +10 more
openaire   +4 more sources