Results 141 to 150 of about 877,581 (317)

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Fast discharge detection based on improved YOLOv5 algorithm

Journal of Engineering and Applied Science
This paper proposes an improved rapid discharge monitoring algorithm based on the YOLOv5 framework for real-time partial discharge detection and localization in GIS using fiber scopes and cameras.
Yanhui Meng, Jining Zhao, Zhilong Zhao, Xiaodan Fan, Zhanning Wang, Lei Zhao, Keyu Li   +6 more
doaj   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Optimization of voltage doublers for energy harvesting applications

, 2013
Energy harvesting is increasingly enabling the expansion of wireless sensor networks in challenging applications by replacing batteries in low power sensors. Many forms of energy harvester suffer from low output voltage which can be partially compensated
Judd, Martin, Roscoe, Nina
core  

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

An improved YOLOv9-based method for identifying insulator temperature anomalies

Journal of Engineering and Applied Science
Abnormal heating of transmission-line insulators is often an early indicator of impending faults. Timely and accurate identification of overheated regions in infrared imagery is therefore critical for the safe operation of power grids.
Cheng Chi, Xiaomeng Yang, Yang Yi, Lihui Liang, Min Yan, Pengfei Ji   +5 more
doaj   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

Structural health monitoring of high voltage electrical switch ceramic insulators in seismic areas [PDF]

, 2014
High voltage electrical switches are crucial components to restart rapidly the electrical network right after an earthquake. But there currently exists no automatic procedure to check if these ceramic insulators have suffered after an earthquake, and ...
BARTHES, Clément, MECHBAL, Nazih, Barthes, Clement B., MOSALAM, Khalid M., RÉBILLAT, Marc   +4 more
core  

Markov modeling of performance deterioration in irradiated resistive plate chambers

European Physical Journal C: Particles and Fields
This work presents a piecewise deterministic Markov process model for describing performance deterioration in resistive plate chambers (RPC) under uniform background irradiation.
Dario Stocco, Michele Pulver, Christian M. Franck   +2 more
doaj   +1 more source