Results 81 to 90 of about 103,384 (304)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Bottlenecks reduction using superconductors in high voltage transmission lines

MATEC Web of Conferences, 2016
Energy flow bottlenecks in high voltage transmission lines known as congestions are one of the challenges facing power utilities in fast developing countries.
Daloub Labib, Khrwat Abdulatif, Ibsaim Rajeb, Regeai Mohamed   +3 more
doaj   +1 more source

Electrical power infrastructure for modern rolling stock with regard to the railway in Poland [PDF]

Archives of Transport, 2017
Implementing high-speed trains on Polish railway lines requires a new approach to the issue of power and energy supply via a 3 kV DC power system. Due to the control systems used, modern rolling stock equipped with asynchronous drive allows maintaining a
Adam Szeląg
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Rating methodology of high voltage mass impregnated DC cable circuits [PDF]

, 2014
With the continuing growth in energy consumption worldwide, the move towards a European wide super grid will result in significant changes in how modern transmission and distribution networks are operated.
Huang, Ziyi
core  

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

SYNTHESIS OF AN ACTIVE SHIELDING SYSTEM OF THE MAGNETIC FIELD OF POWER LINES BASED ON MULTIOBJECTIVE OPTIMIZATION

Electrical engineering & Electromechanics, 2016
Purpose. The synthesis of the active shielding systems by technogenic magnetic field generated by the different types of high voltage power lines in a given region of space using various cables of controlled magnetic field sources. Methodology.
B. I. Kuznetsov, T. B. Nikitina, A. V. Voloshko, I. V. Bovdyj, E. V. Vinichenko, B. B. Kobilyanskiy   +5 more
doaj   +1 more source

Hidden high voltage safety risks for parallel high voltage transmission lines [PDF]

, 2017
High voltage (HV) infrastructures market is growing due to the corresponding growth in industries and population. To ensure continuous and reliable electrical power supply, existing substation and transmission lines are being upgraded to accommodate the ...
Nassereddine, Mohamad (R18981), Karami, N., Hellany, Ali (R8993), Nagrial, Mahmood H. (R8279), Moubayed, Nazih, Rizk, Jamal (R8473)   +5 more
core  

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Research on electromagnetic induction characteristics of HVTL based on improved XGboost integrated machine learning

AIP Advances
With the expansion of transmission demand in the power system, high-voltage transmission technology has been widely applied in the field of transmission.
Ye Wang, Hao Chen, Honghua Xu, Xuchao Ren, Liwei Wang, Tao Huang, Xiaoyu Li   +6 more
doaj   +1 more source