Results 101 to 110 of about 8,004 (311)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Efficiency Optimization by Considering the High Voltage Flyback Transformer Parasitics using an Automatic Winding Layout Technique [PDF]

, 2015
This paper presents an efficiency optimization approach for a high voltage bidirectional flyback dc-dc converter.The main goal is to optimize the converter for driving a capacitive actuator, which must be charged and discharged from 0 V to2.5 kV dc and ...
Thummala, Prasanth, Knott, Arnold, Schneider, Henrik, Zhang, Zhe, Ouyang, Ziwei, Andersen, Michael A. E.   +5 more
core   +1 more source

Leakage Inductance Reduction Using the Interleaved Winding Technique in High-Frequency Toroidal Transformers

International Journal of Technology
High leakage inductance in transformers is the main cause of excessive voltage spikes and ringing waveforms in dc-dc converters. Therefore, reducing leakage inductance is important in the design of power electronic devices.
Dody Yunus Putra Siregar, Wijono, Muhammad Aziz Muslim   +2 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Evaluation of Trends in Optimal Design of Pulse Transformers for Long Pulse High Power Applications

, 2019
Solid state klystron modulators are typically based on oil-immersed pulse transformers due to their high performance, robustness, simplicity and straightforward design.
Martins, Carlos A.,, Collins, Max,, Lund University.   +2 more
core   +1 more source

Electromagnetic Characterization and Parameter Calculation of the Superconducting Ultra-high Voltage Synchronous Condenser

Journal of Harbin University of Science and Technology
The superconducting ultra-high voltage synchronous condenser adopts high-voltage cable winding as stator winding, which can be directly connected to the power grid without a step-up transformer, and the special structure of its stator with non-magnetic ...
XIAOShiyong, ZHENGZhong, GEBaojun, ZHANGJiancheng   +3 more
doaj   +1 more source

High-performance voltage control scheme for wind park integration

IET Renewable Power Generation, 2007
The design and implementation of a new control scheme for reactive power compensation and voltage regulation in the transmission system, as provided and controlled by a wind park is presented. It proposes an optimal tracking secondary voltage control scheme applied to doubly fed induction generator-based wind generators.
M. El Moursi, G. Joos, C. Abbey
openaire   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source