Results 121 to 130 of about 8,004 (311)
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
, 2012 Includes bibliographical references.Keeping generators available on-line is a major factor in achieving maximum productivity in power generation. During operation, generator components are continuously exposed to thermal, electrical, mechanical and ...
Mark Anthony Bruintjies +1 more
core
EnergiesBy combining a coupled inductor with voltage multipliers, the voltage gain of a boost converter can be improved significantly. This method has good application prospects in renewable energy generation and in DC microgrids.
Jiuxu Song +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
, 2004 The paper provides an overview of power applications of High Temperature Superconductivity (HTS) with emphasis on superconducting transformers. Properties of available HTS materials are reviewed and modelling aspects briefly introduced.
Sykulski, Jan
core
Feasibility of high-frequency alternating current power for motor auxiliary loads in vehicles
, 2011 This paper presents a feasibility study into the application of a 100-V, 50-kHz high-frequency ac (HFAC) network for powering automotive electrical auxiliaries. The study is focused on motor-actuated loads and is divided into two sections.
Nicholas D. Vaughan +5 more
core +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
, 2013 The advent of high-temperature superconducting (HTS) materials has renewed interest in the possibilities for superconducting power apparatus offering real economic benefit, within power ratings typical of present system practice.
Sykulski, Jan K.
core
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source