Results 81 to 90 of about 416,002 (260)

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

DMCpy: A powder and single crystal neutron diffraction software for the DMC diffractometer

SoftwareX
The recently upgraded DMC diffractometer at SINQ, Paul Scherrer Institute, Switzerland, equipped with a state-of-the-art 2D 3He detector, enables high-resolution neutron diffraction experiments optimized for both powder and single-crystal studies.
Jakob Lass, Samuel Harrison Moody, Øystein Slagtern Fjellvåg   +2 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Real-time audio spectrum analysis and dynamic volume control system based on FFT

Egyptian Informatics Journal
Traditional sound mixers are often implemented using analog circuits, which have problems such as long response time and low adjustment accuracy. Therefore, this study designs a musical instrument tuning system based on Field Programmable Gate Array ...
Renjie Huang, Hongyang Huang
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Development and Application of Concentric Electric Downhole Measuring and Regulating Instrument

Shiyou jixie, 2016
To address the issues of multizone water injection in directional well like low success rate and efficiency of measuring and regulating and low precision of measuring and regulating small volume water injection,a concentric electric downhole measuring ...
Yu Jiuzheng, Ju Yafeng, Yang Lingzhi
doaj  

Thorium determination in seawater by inductively coupled plasma mass spectrometry: Method development and oceanographic applications

Talanta Open
Thorium isotopes in the ocean (including radiogenic isotopes and terrigenous-derived 232Th) serve as key tracers for studying land-derived material transport. While high-sensitivity and high-resolution inductively coupled plasma mass spectrometry (ICP-MS)
Yingjie Zou, Peng Wang, Lei Xu, Hong Ren, Yiyao Cao   +4 more
doaj   +1 more source

Recherche cotonnière : comment utiliser les chaînes HVI (High Volume Instrument) en amélioration variétale ? [PDF]

, 1994
L'utilisation des chaînes de mesure à haute capacité (High Volume Instrument), notamment aux Etats Unis pour la classification commerciale des cotons, donne un rôle important à la qualité de la fibre. Les essais du laboratoire de technologie cotonnière du CIRAD montrent que l'emploi des chaînes HVI dans les programmes d'amélioration variétale est ...
Gourlot, Jean-Paul, Héquet, Eric
openaire  

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source