Results 101 to 110 of about 422,503 (299)

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Advances in atmospheric temperature profile measurements using high spectral resolution lidar

EPJ Web of Conferences, 2018
This paper reports the atmospheric temperature profile measurements using a University of Wisconsin-Madison High Spectral Resolution Lidar (HSRL) and describes improvements in the instrument performance.
Razenkov Ilya I., Eloranta Edwin W.
doaj   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Optical Computed-Tomographic Microscope for Three-Dimensional Quantitative Histology

Cellular Oncology, 2004
A novel optical computed‐tomographic microscope has been developed allowing quantitative three‐dimensional (3D) imaging and analysis of fixed pathological material.
Ravil Chamgoulov, Pierre Lane, Calum MacAulay   +2 more
doaj   +1 more source

SDSS-V local volume mapper instrument: Overview and status

, 2020
The Sloan Digital Sky Survey V (SDSS-V) is an all-sky spectroscopic survey of >6 million objects, designed to decode the history of the Milky Way, reveal the inner workings of stars, investigate the origin of solar systems, and track the growth of ...
Lanz, A.E., Feger, T., Hauser, A., Lawrence, J., Bershady, M.A., Hull, C.L., Hebert, A., Lesser, M., Konidaris, N.P., Drory, N., Pellegrini, E., Chattopadhyay, S., Blanc, G.A., Bilgi, P., Pak, S., Sanchez-Gallego, J., Wolf, M.J., Almeida, A., Froning, C.S., Wachter, S., Yan, R., Smith, M., Kreckel, K., Zhelem, R., Kollmeier, J.A., Case, S., Ramirez, S., Herbst, T.   +27 more
core   +1 more source

Repeatability of Joint-Dominated Deployable Masts [PDF]

, 2011
Deployable masts are a class of structure that can be stowed in a small volume and expanded into long, slender, and stable booms. Their greatest benefit as space structures is their packing ratio: masts can typically be packed to a fraction of their ...
Stohlman, OR, Stohlman, Olive Remington
core   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Technical Evaluation of Cutting Device for Volume Reduction of High Radio-Activated Instruments [PDF]

Proceedings of the 14th International Workshop on Spallation Materials Technology, 2020
Eiichi Wakai, Hideyuki Nemoto, Hidetaka Kinoshita, Takashi Wakui, Masahide Harada, Hiroshi Takada, Kouji Ishikawa   +6 more
openaire   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source