Results 101 to 110 of about 416,002 (260)

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

ABCD Model for Prioritizing Calibration of Measuring Instruments in Industrial Environments with High Equipment Volume

Accurate and regular calibration of measuring instruments plays a vital role in maintaining product quality and the safety of industrial processes. In busy workshops, prioritizing the calibration of instruments is of great importance. This paper presents a simple and practical model named ABCD, which categorizes measuring instruments into four groups ...
openaire   +2 more sources

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

The high-energy proton instrument (HEPI), a compact Cherenkov radiation space weather monitor

Journal of Space Weather and Space Climate
The monitoring of near-Earth space radiation has been a key component of space agencies’ strategies since their inception. The changes in these radiation fluxes, part of the broader space weather environment, originate from various sources, including ...
O’Neill Joseph, Lei Fan, Ryden Keith, Morris Paul, Clewer Ben, Baird Fraser, Sellin Paul, Dyer Clive, Heil Melanie, Jiggens Piers, Santin Giovanni   +10 more
doaj   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

The effect of cotton fibre characteristics on the measurement of their resistance to rupture. Contribution to the study of the quality of measurements made using high volume instruments (HVI) [PDF]

, 2003
Cotton fiber strength as measured by HVI is the results of a calculation taking into account the results from a mechanical test and from an optical characterization of the number of broken fibers. This poster presents the general conditions that were used to check the precision and the accuracy of the strength measurement on a set of cotton covering a ...
Gourlot, Jean-Paul, Frydrych, Richard, Renner, Marc   +2 more
openaire  

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

High-Volume Precipitation Spectrometer (HVPS) Instrument Handbook

, 2020
Susanne Glienke, Fan Mei
openaire   +2 more sources

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Inter‐Instrument Variability of Vaisala CL61 Lidar‐Ceilometer's Attenuated Backscatter, Cloud Properties and Mixed‐Layer Height

Meteorological Applications
Characterizing inter‐instrument variability of sensors is crucial to assessing uncertainties in observational campaigns, networks, and for data assimilation. Here, we co‐locate six high signal‐to‐noise ratio Vaisala CL61 lidar‐ceilometers for a period of
Dana Looschelders, Andreas Christen, Sue Grimmond, Simone Kotthaus, Daniel Fenner, Jean‐Charles Dupont, Martial Haeffelin, William Morrison   +7 more
doaj   +1 more source